PMID- 29668337
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20200505
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 56
IP  - 4
DP  - 2019 Apr
TI  - Reduced longitudinal cardiac strain in asthma patients.
PG  - 350-359
LID - 10.1080/02770903.2018.1466311 [doi]
AB  - OBJECTIVE: There is limited knowledge about the potential relationship between 
      asthma and heart function. Aim of our present study was to examine if asthma may 
      be associated with manifest or subclinical heart dysfunction. METHODS: 
      Seventy-two allergic mild-to-moderate and severe asthma patients and 20 matched 
      controls were enrolled in the study. Depending on the anti-asthmatic therapy, 
      four subgroups of asthma patients were created: patients under long-acting 
      beta2-agonists (LABA) and inhaled cortisone without oral cortisone treatment with 
      (1a) versus without (1b) additional omalizumab therapy; patients with LABA, 
      inhaled cortisone and omalizumab treatment with (2a) versus without (2b) oral 
      cortisone. Standard echocardiographic parameters as well as global longitudinal 
      left and right ventricular strains as determined by ultrasound-based 
      speckle-tracking method were evaluated. Furthermore, NT-pro-brain natriuretic 
      peptide (NT-pro-BNP), immunoglobulin E (IgE), C-reactive protein (CRP), and blood 
      count were assessed in asthma and control groups. RESULTS: There were no relevant 
      differences in standard echocardiographic measures between both asthma groups and 
      the control collective. Longitudinal left ventricular strain values were reduced 
      significantly in severe and mild-to-moderate asthma groups (-12.91 +/- 0.84% and 
      -13.92 +/- 1.55%, respectively), whereas longitudinal right ventricular strain 
      values were additionally relevantly decreased in severe asthma (-10.35 +/- 1.04%) 
      compared to the control (-16.55 +/- 0.49% and -18.48 +/- 1.90%, respectively). 
      Cardiac strains were similar in subgroups 1a and 1b. In contrast, patients from 
      subgroup 2a presented reduced heart strains and decreased lung function compared 
      to those from 2b. CRP, IgE, and eosinophils were significantly increased in 
      asthma versus control individuals. CONCLUSIONS: Allergic asthma, especially 
      severe asthma is associated with subclinical impaired left and right ventricular 
      function as determined by speckle-tracking analysis.
FAU - Tuleta, I
AU  - Tuleta I
AD  - a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , 
      University of Bonn , Bonn , Germany.
FAU - Eckstein, N
AU  - Eckstein N
AD  - a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , 
      University of Bonn , Bonn , Germany.
FAU - Aurich, F
AU  - Aurich F
AD  - a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , 
      University of Bonn , Bonn , Germany.
FAU - Nickenig, G
AU  - Nickenig G
AD  - a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , 
      University of Bonn , Bonn , Germany.
FAU - Schaefer, C
AU  - Schaefer C
AD  - a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , 
      University of Bonn , Bonn , Germany.
FAU - Skowasch, D
AU  - Skowasch D
AD  - a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , 
      University of Bonn , Bonn , Germany.
FAU - Schueler, R
AU  - Schueler R
AD  - a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , 
      University of Bonn , Bonn , Germany.
LA  - eng
PT  - Journal Article
DEP - 20180518
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Administration, Inhalation
MH  - Adult
MH  - Analysis of Variance
MH  - Anti-Asthmatic Agents
MH  - Asthma/diagnosis/*drug therapy/*epidemiology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Drug Therapy, Combination
MH  - Echocardiography/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Incidence
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Tomography, X-Ray Computed/methods
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*epidemiology
MH  - Ventricular Dysfunction, Right/diagnostic imaging/*epidemiology
OTO - NOTNLM
OT  - Allergic asthma
OT  - echocardiography
OT  - heart dysfunction
OT  - longitudinal ventricular strain
OT  - speckle-tracking analysis
EDAT- 2018/04/19 06:00
MHDA- 2020/05/06 06:00
CRDT- 2018/04/19 06:00
PHST- 2018/04/19 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2018/04/19 06:00 [entrez]
AID - 10.1080/02770903.2018.1466311 [doi]
PST - ppublish
SO  - J Asthma. 2019 Apr;56(4):350-359. doi: 10.1080/02770903.2018.1466311. Epub 2018 
      May 18.