PMID- 29668344
OWN - NLM
STAT- MEDLINE
DCOM- 20181002
LR  - 20181202
IS  - 1521-0758 (Electronic)
IS  - 0191-3123 (Linking)
VI  - 42
IP  - 3
DP  - 2018 May-Jun
TI  - Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair 
      in a model of immunoglobulin light chain-associated mesangial damage.
PG  - 262-288
LID - 10.1080/01913123.2018.1449772 [doi]
AB  - Mesangiopathies produced by glomerulopathic monoclonal immunoglobulin light 
      chains (GLCs) acting on the glomerular mesangium produce two characteristic 
      lesions: AL-amyloidosis (AL-Am) and light chain deposition disease (LCDD). In 
      both cases, the pathology is centered in the mesangium, where initial and 
      progressive damage occurs. In AL-Am the mesangial matrix is destroyed and 
      replaced by amyloid fibrils and in LCDD, the mesangial matrix is increased and 
      remodeled. The collagen IV rich matrix is replaced by tenascin. In both 
      conditions, mesangial cells (MCs) become apoptotic as a direct effect of the 
      GLCs. MCs were incubated in-vitro with GLCs and animal kidneys were perfused 
      ex-vivo via the renal artery with GLCs, producing expected lesions, and then 
      mesenchymal stem cells (MSCs) were added to both platforms. Each of the two 
      platforms provided unique information that when put together created a 
      comprehensive evaluation of the processes involved. A "cocktail" with growth and 
      differentiating factors was used to study its effect on mesangial repair. MSCs 
      displayed remarkable phenotypic plasticity during the repair process. The first 
      role of the MSCs after migrating to the affected areas was to dispose of the 
      amyloid fibrils (in AL-Am), the altered mesangial matrix (in LCDD) and apoptotic 
      MCs/debris. To accomplish this task, MSCs transformed into facultative 
      macrophages acquiring an abundance of lysosomes and endocytotic capabilities 
      required to engage in phagocytic functions. Once the mesangial cleaning was 
      completed, MSCs transformed into functional MCs restoring the mesangium to 
      normal. "Cocktail" made the repair process more efficient.
FAU - Herrera, Guillermo A
AU  - Herrera GA
AD  - a Departments of Pathology and Translational Pathobiology and Cell Biology and 
      Anatomy , Louisiana State Health Sciences Center , Shreveport , LA , USA.
FAU - Teng, Jiamin
AU  - Teng J
AD  - b Department of Pathology and Translational Pathobiology , Louisiana State Health 
      Sciences Center , Shreveport , LA , USA.
FAU - Zeng, Chun
AU  - Zeng C
AD  - b Department of Pathology and Translational Pathobiology , Louisiana State Health 
      Sciences Center , Shreveport , LA , USA.
FAU - Xu, Hongzhi
AU  - Xu H
AD  - b Department of Pathology and Translational Pathobiology , Louisiana State Health 
      Sciences Center , Shreveport , LA , USA.
FAU - Liang, Man
AU  - Liang M
AD  - b Department of Pathology and Translational Pathobiology , Louisiana State Health 
      Sciences Center , Shreveport , LA , USA.
FAU - Alexander, J Steven
AU  - Alexander JS
AD  - c Department of Molecular and Cellular Physiology , Louisiana State Health 
      Sciences Center , Shreveport , LA , USA.
FAU - Liu, Bing
AU  - Liu B
AD  - b Department of Pathology and Translational Pathobiology , Louisiana State Health 
      Sciences Center , Shreveport , LA , USA.
FAU - Boyer, Chris
AU  - Boyer C
AD  - c Department of Molecular and Cellular Physiology , Louisiana State Health 
      Sciences Center , Shreveport , LA , USA.
FAU - Turbat-Herrera, Elba A
AU  - Turbat-Herrera EA
AD  - d Departments of Pathology and Translational Pathobiology , Medicine, and Cell 
      Biology and Anatomy, Louisiana State Health Sciences Center , Shreveport , LA , 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20180418
PL  - England
TA  - Ultrastruct Pathol
JT  - Ultrastructural pathology
JID - 8002867
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Disease Models, Animal
MH  - Glomerular Mesangium/*pathology
MH  - Humans
MH  - Immunoglobulin Light Chains
MH  - Mesangial Cells/*cytology
MH  - Mesenchymal Stem Cells/*cytology
MH  - Mice
MH  - Phenotype
MH  - Rats
MH  - Renal Insufficiency, Chronic/*pathology
OTO - NOTNLM
OT  - Mesenchymal stem cells
OT  - amyloidosis
OT  - light chain deposition disease
OT  - mesangial repair
OT  - mesangium
EDAT- 2018/04/19 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/04/19 06:00
PHST- 2018/04/19 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/04/19 06:00 [entrez]
AID - 10.1080/01913123.2018.1449772 [doi]
PST - ppublish
SO  - Ultrastruct Pathol. 2018 May-Jun;42(3):262-288. doi: 
      10.1080/01913123.2018.1449772. Epub 2018 Apr 18.