PMID- 29671049
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20191025
IS  - 1432-1351 (Electronic)
IS  - 0340-7594 (Linking)
VI  - 204
IP  - 6
DP  - 2018 Jun
TI  - Parent-offspring cohabitation after weaning inhibits partner preference and 
      alters central oxytocin and dopamine systems in adult mandarin vole.
PG  - 593-604
LID - 10.1007/s00359-018-1262-4 [doi]
AB  - In some mammals, offspring may live with their parents for a very long time after 
      weaning, but little is known about the effect of post-weaning parent-offspring 
      cohabitation on the behavioral and neurobiological development of offspring. 
      Here, we explored the effect of this experience on partner preference in adult 
      mandarin vole (Microtus mandarinus). Levels of central oxytocin (OT), tyrosine 
      hydroxylase (TH), as well as OT receptor (OTR), dopamine D1-type and D2-type 
      receptors (D1R and D2R) mRNA expression in the nucleus accumbens (NAcc) and 
      medial amygdala (MeA) were also measured. Our data showed that post-weaning 
      living with parents inhibited the preference to partner over an unfamiliar 
      opposite-sex conspecific. Voles with this experience possessed more OT-but less 
      TH-immunoreactive neurons as compared to the control. Additionally, males with 
      this experience had less D2R and OTR mRNA expression in the NAcc than the control 
      while females had less D2R mRNA expression in the NAcc, but more OTR mRNA 
      expression in the MeA. These findings demonstrate that post-weaning 
      parent-offspring cohabitation inhibits the partner preference formation at 
      adulthood, and these changes may be associated with alterations in the levels of 
      central OT and DA, and their receptor mRNA expression in specific brain regions.
FAU - Wu, Ruiyong
AU  - Wu R
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, Shaanxi, China. wuruiyong@yzu.edu.cn.
AD  - Department of Animal Behavior, College of Bioscience and Biotechnology, Yangzhou 
      University, Yangzhou, 225009, Jiangsu, China. wuruiyong@yzu.edu.cn.
FAU - Song, Zhenzhen
AU  - Song Z
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, Shaanxi, China.
AD  - Department of Animal Behavior, College of Bioscience and Biotechnology, Yangzhou 
      University, Yangzhou, 225009, Jiangsu, China.
FAU - Tai, Fadao
AU  - Tai F
AUID- ORCID: 0000-0002-6804-4179
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, 710062, Shaanxi, China. taifadao@snnu.edu.cn.
AD  - Department of Psychology, Wright State University, Dayton, OH, USA. 
      taifadao@snnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180418
PL  - Germany
TA  - J Comp Physiol A Neuroethol Sens Neural Behav Physiol
JT  - Journal of comparative physiology. A, Neuroethology, sensory, neural, and 
      behavioral physiology
JID - 101141792
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Receptors, Oxytocin)
RN  - 50-56-6 (Oxytocin)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - Amygdala/metabolism
MH  - Animals
MH  - Arvicolinae/*metabolism
MH  - Fathers
MH  - Female
MH  - Housing, Animal
MH  - Male
MH  - Mating Preference, Animal/*physiology
MH  - Mothers
MH  - Nesting Behavior/*physiology
MH  - Nucleus Accumbens/metabolism
MH  - Oxytocin/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptors, Dopamine D1/*metabolism
MH  - Receptors, Dopamine D2/*metabolism
MH  - Receptors, Oxytocin/metabolism
MH  - Tyrosine 3-Monooxygenase/metabolism
MH  - Weaning
OTO - NOTNLM
OT  - Dopamine
OT  - Mandarin vole
OT  - Oxytocin
OT  - Partner preference
OT  - Tyrosine hydroxylase
EDAT- 2018/04/20 06:00
MHDA- 2019/10/28 06:00
CRDT- 2018/04/20 06:00
PHST- 2017/09/19 00:00 [received]
PHST- 2018/04/13 00:00 [accepted]
PHST- 2018/04/11 00:00 [revised]
PHST- 2018/04/20 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
PHST- 2018/04/20 06:00 [entrez]
AID - 10.1007/s00359-018-1262-4 [pii]
AID - 10.1007/s00359-018-1262-4 [doi]
PST - ppublish
SO  - J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2018 Jun;204(6):593-604. 
      doi: 10.1007/s00359-018-1262-4. Epub 2018 Apr 18.