PMID- 29671415
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20240325
IS  - 1745-7254 (Electronic)
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 39
IP  - 5
DP  - 2018 May
TI  - Phoenixin: uncovering its receptor, signaling and functions.
PG  - 774-778
LID - 10.1038/aps.2018.13 [doi]
AB  - Phoenixin (PNX) is a newly discovered peptide that has been linked to 
      reproductive function, both in the hypothalamus and pituitary. This review will 
      focus on the most recent discoveries related to this novel neuropeptide. 
      Initially, it was found that PNX increased gonadotropin releasing hormone 
      (GnRH)-stimulated luteinizing hormone (LH) release from pituitary cells. 
      Importantly, knockdown of PNX in female rats extended the estrous cycle by 2.3 
      days. Using novel hypothalamic cell lines, we found that PNX has a stimulatory 
      role on kisspeptin (Kiss) and GnRH gene expression and secretion. The PNX 
      receptor was uncovered using siRNA knockdown of GPR173, an orphan receptor 
      postulated to bind PNX. We have found that the PNX-R signaling through protein 
      kinase A (PKA) in hypothalamic neurons. Althuogh a number of studies demonstrate 
      that PNX plays an important role in reproductive function, there is also evidence 
      that it may have other functions, regulating the heart, feeding, memory, and 
      anxiety, both in the brain and the periphery.
FAU - Mcilwraith, Emma K
AU  - Mcilwraith EK
AD  - Departments of Physiology.
FAU - Belsham, Denise D
AU  - Belsham DD
AD  - Departments of Physiology.
AD  - Obstetrics and Gynaecology and Medicine, University of Toronto, Toronto, ON, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180419
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
RN  - 0 (GPR173 protein, mouse)
RN  - 0 (Hypothalamic Hormones)
RN  - 0 (PNX-14 peptide, mouse)
RN  - 0 (Peptide Hormones)
RN  - 0 (Peptides)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (gpr173 protein, rat)
RN  - 0 (phoenixin-14, rat)
RN  - 0 (phoenixin-20)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Feeding Behavior/physiology
MH  - Female
MH  - Gonadotropin-Releasing Hormone/metabolism
MH  - Humans
MH  - Hypothalamic Hormones/*metabolism
MH  - Hypothalamus/metabolism
MH  - Male
MH  - Memory/physiology
MH  - Myocardium/metabolism
MH  - Peptide Hormones/*metabolism
MH  - Peptides/*metabolism
MH  - Receptors, G-Protein-Coupled/*metabolism
MH  - Spinal Cord/metabolism
PMC - PMC5943909
EDAT- 2018/04/20 06:00
MHDA- 2018/10/12 06:00
PMCR- 2019/05/01
CRDT- 2018/04/20 06:00
PHST- 2017/11/25 00:00 [received]
PHST- 2018/02/28 00:00 [accepted]
PHST- 2018/04/20 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2018/04/20 06:00 [entrez]
PHST- 2019/05/01 00:00 [pmc-release]
AID - aps201813 [pii]
AID - 10.1038/aps.2018.13 [doi]
PST - ppublish
SO  - Acta Pharmacol Sin. 2018 May;39(5):774-778. doi: 10.1038/aps.2018.13. Epub 2018 
      Apr 19.