PMID- 29671674 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2045-8932 (Print) IS - 2045-8940 (Electronic) IS - 2045-8932 (Linking) VI - 8 IP - 2 DP - 2018 Apr-Jun TI - Pulmonary hypertension in chronic lung diseases: comparison to other pulmonary hypertension groups. PG - 2045894018775056 LID - 10.1177/2045894018775056 [doi] LID - 2045894018775056 AB - Group 3 pulmonary hypertension (PH) is a common complication of advanced chronic lung disease. Our hypothesis was that group 3 PH is associated with a more severe baseline presentation and a more severe prognosis compared to group 1 pulmonary arterial hypertension (PAH), chronic thromboembolic PH (group 4), and group 5 PH. We retrospectively analyzed consecutive incident PH patients in a single center between January 2006 and November 2014. Data were acquired from a prospective database. Clinical, functional, and hemodynamic characteristics, as well as survival, were compared between the four groups of precapillary PH. A total of 363 patients were analyzed; 164 patients (45.2%) belonged to group 1 PAH, 109 (30%) to group 3 PH, 65 (17.9%) to group 4 PH, and 25 (6.9%) to group 5 PH. Group 3 patients were predominantly male and were more frequently in New York Heart Association (NYHA) class III/IV. Patients with group 3 and 4 PH were older, had significantly lower 6-min walking distance (6MWD), higher mean pulmonary arterial pressure, higher pulmonary vascular resistance (PVR), and lower cardiac index (CI) than PAH patients. Group 3 and 5 patients had significantly lower total lung capacity (TLC), forced vital capacity (FVC), and FEV1; group 3 patients had the lowest carbon monoxide transfer coefficient values. PH therapy was used in 90.9% of group 3 patients. Univariate analysis of prognostic factors in the overall population showed that age, male gender, NYHA class, groups 3 and 4 PH (vs. PAH), 6MWD, FVC, TLC, carbon monoxide transfer coefficient (KCO), PVR, CI, and venous oxygen saturation were significantly associated with greater mortality. Multivariate analysis showed that age, PH group 4, 6MWD, and KCO but no longer PH group 3 were significantly associated with mortality. Patients with group 3 PH are older, have more severe baseline presentation and lower survival rates than PAH patients in univariate analysis, that seemed to be related to older age. FAU - Chebib, Nader AU - Chebib N AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. FAU - Mornex, Jean-Francois AU - Mornex JF AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. AD - 2 Claude Bernard Lyon 1 University, University of Lyon, Lyon, France. FAU - Traclet, Julie AU - Traclet J AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. FAU - Philit, Francois AU - Philit F AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. FAU - Khouatra, Chahera AU - Khouatra C AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. FAU - Zeghmar, Sabrina AU - Zeghmar S AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. FAU - Turquier, Segolene AU - Turquier S AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. FAU - Cottin, Vincent AU - Cottin V AD - 1 Hospices Civils de Lyon, National Reference Center for Rare Pulmonary Diseases, Competence Center for Severe Pulmonary Hypertension, Lyon, France. AD - 2 Claude Bernard Lyon 1 University, University of Lyon, Lyon, France. LA - eng PT - Journal Article DEP - 20180419 PL - United States TA - Pulm Circ JT - Pulmonary circulation JID - 101557243 PMC - PMC6012471 OTO - NOTNLM OT - emphysema OT - interstitial lung disease OT - pulmonary hypertension EDAT- 2018/04/20 06:00 MHDA- 2018/04/20 06:01 PMCR- 2018/04/05 CRDT- 2018/04/20 06:00 PHST- 2018/04/20 06:00 [pubmed] PHST- 2018/04/20 06:01 [medline] PHST- 2018/04/20 06:00 [entrez] PHST- 2018/04/05 00:00 [pmc-release] AID - 10.1177_2045894018775056 [pii] AID - 10.1177/2045894018775056 [doi] PST - ppublish SO - Pulm Circ. 2018 Apr-Jun;8(2):2045894018775056. doi: 10.1177/2045894018775056. Epub 2018 Apr 19.