PMID- 29673068
OWN - NLM
STAT- MEDLINE
DCOM- 20190603
LR  - 20201209
IS  - 1742-4658 (Electronic)
IS  - 1742-464X (Linking)
VI  - 285
IP  - 15
DP  - 2018 Aug
TI  - Molecular definition of the transplantation antigens.
PG  - 2728-2745
LID - 10.1111/febs.14474 [doi]
AB  - In the first half of the 20th century, the major histocompatibility complex (MHC) 
      of the laboratory mouse, the H-2 complex, was defined by a combination of 
      serology and genetics. In the second half of the 20th century, its human 
      counterpart, the human leukocyte antigen (HLA) complex was similarly defined and 
      shown to mediate rejection of allogeneic kidney grafts. The clinical relevance of 
      the transplantation antigens created the field of transplant immunology, which 
      aimed to reduce graft rejection by HLA matching of transplant donors and 
      recipients, and to use immunosuppressive drugs to prevent and treat rejection. 
      Because tissue transplantation is not a natural phenomenon, the relevance of the 
      MHC for immunology and immune defense against microbial pathogens was frequently 
      questioned. In the 1970s, the general observation that cytotoxic T-cell responses 
      to viral infection required recognition of both a viral antigen and a 
      transplantation antigen argued for the immunological importance of the MHC. 
      Proving this point was not achieved until close to the end of the 20th century. 
      This required detailed biochemical and structural analysis of the transplantation 
      antigens, the viral antigens, and the T-cell receptors that recognized them. This 
      century of research culminated in 1996 with the three-dimensional 
      crystallographic structure of the complex of these three components. In this 
      complex is MAC, the very first HLA antigen to be detected and now more formally 
      known as HLA-A*02:01.
CI  - (c) 2018 Federation of European Biochemical Societies.
FAU - Parham, Peter
AU  - Parham P
AD  - Departments of Structural Biology and Microbiology & Immunology, School of 
      Medicine, Stanford University, CA, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20180501
PL  - England
TA  - FEBS J
JT  - The FEBS journal
JID - 101229646
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (H-2 Antigens)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PDZD2 protein, human)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/chemistry/immunology
MH  - Animals
MH  - Cell Adhesion Molecules
MH  - Female
MH  - Graft Rejection/immunology
MH  - Graft Survival/immunology
MH  - H-2 Antigens/chemistry
MH  - Histocompatibility Antigens/*chemistry/history/*physiology
MH  - History, 20th Century
MH  - Humans
MH  - Mice
MH  - Neoplasm Proteins/chemistry/immunology
MH  - Pregnancy
MH  - Skin Transplantation
MH  - Solubility
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - *Tissue Transplantation
MH  - beta 2-Microglobulin/immunology
OTO - NOTNLM
OT  - crystal structures
OT  - genetic polymorphism
OT  - graft rejection
OT  - immune response
OT  - immunology
OT  - major histocompatibility complex
OT  - membrane proteins
OT  - transplantation
OT  - viral antigens
EDAT- 2018/04/20 06:00
MHDA- 2019/06/04 06:00
CRDT- 2018/04/20 06:00
PHST- 2018/03/08 00:00 [received]
PHST- 2018/04/12 00:00 [accepted]
PHST- 2018/04/20 06:00 [pubmed]
PHST- 2019/06/04 06:00 [medline]
PHST- 2018/04/20 06:00 [entrez]
AID - 10.1111/febs.14474 [doi]
PST - ppublish
SO  - FEBS J. 2018 Aug;285(15):2728-2745. doi: 10.1111/febs.14474. Epub 2018 May 1.