PMID- 29673161
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20190801
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 23
IP  - 4
DP  - 2018 Apr 17
TI  - Biflavonoids Isolated from Selaginella tamariscina and Their Anti-Inflammatory 
      Activities via ERK 1/2 Signaling.
LID - 10.3390/molecules23040926 [doi]
LID - 926
AB  - Selaginella tamariscina (S. tamariscina) (Beauv.) Spring (Selaginellaceae) has 
      been used in oriental medicine for the treatment of dysmenorrhea, chronic 
      hepatitis, hyperglycemia, amenorrhea, hematuria, prolapse of the anus and 
      metrorrhagia. In the present study, we isolated two strong anti-inflammatory 
      compounds, the biflavonoids hinokiflavone (H) and 7'-O-methyl hinokiflavone (mH), 
      from S. tamariscina and examined their anti-inflammatory activities in 
      lipopolysaccharide (LPS)-mediated murine macrophages (RAW 264.7) and colon 
      epithelial cells (HT-29). H and mH suppressed the production of the inflammatory 
      mediators nitric oxide (NO), interleukin (IL)-6, IL-8, and tumor-necrosis factor 
      (TNF)-alpha, which are most highly activated in inflammatory bowel disease (IBD). In 
      addition, Western blot analysis revealed that H and mH suppressed the LPS-induced 
      expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2, 
      and the activation of nuclear factor-kappaB (NF-kappaB) and extracellular regulated 
      kinases (ERK) 1/2. These results suggest that H and mH are compounds having 
      potent anti-inflammatory effects that could be used to treat such diseases as 
      IBD.
FAU - Shim, Sun-Yup
AU  - Shim SY
AD  - College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon-si 
      57922, Jeonnam, Korea. shimsy@sunchon.ac.kr.
AD  - Research Institute of Life and Pharmaceutical Sciences, 255 Jungangno, 
      Suncheon-si 57922, Jeonnam, Korea. shimsy@sunchon.ac.kr.
FAU - Lee, Seul-Gi
AU  - Lee SG
AD  - College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon-si 
      57922, Jeonnam, Korea. thelsg@sunchon.ac.kr.
FAU - Lee, Mina
AU  - Lee M
AD  - College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon-si 
      57922, Jeonnam, Korea. minalee@sunchon.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180417
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Biflavonoids)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*chemistry/*pharmacology
MH  - Biflavonoids/*chemistry/*pharmacology
MH  - Cyclooxygenase 2/metabolism
MH  - HT29 Cells
MH  - Humans
MH  - MAP Kinase Signaling System/drug effects
MH  - Mice
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - RAW 264.7 Cells
MH  - Selaginellaceae/*chemistry
PMC - PMC6017943
OTO - NOTNLM
OT  - 7'-O-methyl hinokiflavone
OT  - HT-29 cells
OT  - RAW 264.7 cells
OT  - Selaginella tamariscina
OT  - hinokiflavone
COIS- The authors declare no conflict of interest.
EDAT- 2018/04/21 06:00
MHDA- 2018/09/18 06:00
PMCR- 2018/04/17
CRDT- 2018/04/21 06:00
PHST- 2018/03/09 00:00 [received]
PHST- 2018/04/11 00:00 [revised]
PHST- 2018/04/13 00:00 [accepted]
PHST- 2018/04/21 06:00 [entrez]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2018/04/17 00:00 [pmc-release]
AID - molecules23040926 [pii]
AID - molecules-23-00926 [pii]
AID - 10.3390/molecules23040926 [doi]
PST - epublish
SO  - Molecules. 2018 Apr 17;23(4):926. doi: 10.3390/molecules23040926.