PMID- 29673858 OWN - NLM STAT- MEDLINE DCOM- 20190319 LR - 20190319 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 191 DP - 2018 Jul 1 TI - Impact of high intensity interval exercise on executive function and brain derived neurotrophic factor in healthy college aged males. PG - 116-122 LID - S0031-9384(18)30194-X [pii] LID - 10.1016/j.physbeh.2018.04.018 [doi] AB - Prefrontal cortex (PFC)-dependent executive function is enhanced immediately following high intensity interval exercise (HIIE). Brain-derived neurotrophic factor (BDNF) is considered a biomarker associated with enhanced execute functioning capacity at rest and in response to exercise. However, the mechanisms responsible for the acute exercise-induced BDNF response in plasma and serum differ, and it is likely that the utilization of BDNF in plasma and/or serum as a biomarker of improved executive function following HIIE may be limited. Therefore, this study examined the impact of HIIE on the plasma and serum BDNF response to understand the efficaciousness of BDNF as a peripheral biomarker associated with improvements in PFC-dependent executive function. Thirteen healthy males (age: 23.62 +/- 1.06 years) participated in a randomized, counterbalanced study, performing the Wisconsin Card Sorting Task (WCST) immediately following a 5-minute seated rest (control) and participation in a HIIE protocol administered two weeks apart. HIIE consisted of ten maximal bouts of all out pedaling on a cycle ergometer for 20 s (separated by 10 s of active recovery) against 5.5% of the subject's body weight. Whole blood was collected for the assessment of BDNF in both plasma and serum. Compared to the control session, HIIE elicited significant improvements in WCST performance, yet improvements in PFC-dependent executive function were independent of BDNF concentrations in plasma and serum. Results from this investigation demonstrate that a single session of low-volume, supramaximal HIIE significantly increases PFC-dependent executive function, thereby providing additional evidence to support the powerful benefits on HIIE on cognitive functioning. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Slusher, Aaron L AU - Slusher AL AD - Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: slusheral@vcu.edu. FAU - Patterson, Virginia T AU - Patterson VT AD - Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA. FAU - Schwartz, Charles S AU - Schwartz CS AD - Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA. FAU - Acevedo, Edmund O AU - Acevedo EO AD - Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA. LA - eng GR - UL1 TR000058/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20180417 PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Analysis of Variance MH - Brain-Derived Neurotrophic Factor/*blood MH - Executive Function/*physiology MH - Exercise/*physiology MH - *High-Intensity Interval Training MH - Humans MH - Male MH - Neuropsychological Tests MH - Oxygen Consumption MH - Prefrontal Cortex/*physiology MH - Students MH - Time Factors MH - Universities MH - Young Adult OTO - NOTNLM OT - Brain derived neurotrophic factor OT - Executive function OT - High intensity interval exercise OT - Prefrontal cortex OT - Wisconsin card sorting task EDAT- 2018/04/21 06:00 MHDA- 2019/03/20 06:00 CRDT- 2018/04/21 06:00 PHST- 2018/01/16 00:00 [received] PHST- 2018/03/20 00:00 [revised] PHST- 2018/04/13 00:00 [accepted] PHST- 2018/04/21 06:00 [pubmed] PHST- 2019/03/20 06:00 [medline] PHST- 2018/04/21 06:00 [entrez] AID - S0031-9384(18)30194-X [pii] AID - 10.1016/j.physbeh.2018.04.018 [doi] PST - ppublish SO - Physiol Behav. 2018 Jul 1;191:116-122. doi: 10.1016/j.physbeh.2018.04.018. Epub 2018 Apr 17.