PMID- 29674046
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20180924
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 184
DP  - 2018 Jul 1
TI  - Development of a chromatographic method with multi-criteria decision making 
      design for simultaneous determination of nifedipine and atenolol in content 
      uniformity testing.
PG  - 296-306
LID - S0039-9140(18)30240-6 [pii]
LID - 10.1016/j.talanta.2018.03.008 [doi]
AB  - A new robust and reliable high-performance liquid chromatography (HPLC) method 
      with multi-criteria decision making (MCDM) approach was developed to allow 
      simultaneous quantification of atenolol (ATN) and nifedipine (NFD) in content 
      uniformity testing. Felodipine (FLD) was used as an internal standard (I.S.) in 
      this study. A novel marriage between a new interactive response optimizer and a 
      HPLC method was suggested for multiple response optimizations of target 
      responses. An interactive response optimizer was used as a decision and 
      prediction tool for the optimal settings of target responses, according to 
      specified criteria, based on Derringer's desirability. Four independent variables 
      were considered in this study: Acetonitrile%, buffer pH and concentration along 
      with column temperature. Eight responses were optimized: retention times of ATN, 
      NFD, and FLD, resolutions between ATN/NFD and NFD/FLD, and plate numbers for ATN, 
      NFD, and FLD. Multiple regression analysis was applied in order to scan the 
      influences of the most significant variables for the regression models. The 
      experimental design was set to give minimum retention times, maximum resolution 
      and plate numbers. The interactive response optimizer allowed prediction of 
      optimum conditions according to these criteria with a good composite desirability 
      value of 0.98156. The developed method was validated according to the 
      International Conference on Harmonization (ICH) guidelines with the aid of the 
      experimental design. The developed MCDM-HPLC method showed superior robustness 
      and resolution in short analysis time allowing successful simultaneous content 
      uniformity testing of ATN and NFD in marketed capsules. The current work presents 
      an interactive response optimizer as an efficient platform to optimize, predict 
      responses, and validate HPLC methodology with tolerable design space for assay in 
      quality control laboratories.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Ahmed, Sameh
AU  - Ahmed S
AD  - Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy Taibah 
      University, Al Madinah AlMunawarah 30001, Saudi Arabia; Department of 
      Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, 
      Assiut 71526, Egypt. Electronic address: shassan@taibahu.edu.sa.
FAU - Alqurshi, Abdulmalik
AU  - Alqurshi A
AD  - Pharmaceutics and Pharmaceutical Technology Department, College of Pharmacy 
      Taibah University, Al Madinah AlMunawarah 30001, Saudi Arabia.
FAU - Mohamed, Abdel-Maaboud Ismail
AU  - Mohamed AI
AD  - Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut 
      University, Assiut 71526, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180307
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Tablets)
RN  - 50VV3VW0TI (Atenolol)
RN  - I9ZF7L6G2L (Nifedipine)
SB  - IM
MH  - Atenolol/*analysis
MH  - Chromatography, High Pressure Liquid/*methods
MH  - *Decision Making
MH  - *Drug Compounding
MH  - Nifedipine/*analysis
MH  - Tablets/chemistry
OTO - NOTNLM
OT  - Atenolol
OT  - Content uniformity testing
OT  - HPLC
OT  - Multi-criteria decision making
OT  - Nifidipine
OT  - Response Optimizer
EDAT- 2018/04/21 06:00
MHDA- 2018/09/25 06:00
CRDT- 2018/04/21 06:00
PHST- 2018/01/28 00:00 [received]
PHST- 2018/03/03 00:00 [revised]
PHST- 2018/03/05 00:00 [accepted]
PHST- 2018/04/21 06:00 [entrez]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
AID - S0039-9140(18)30240-6 [pii]
AID - 10.1016/j.talanta.2018.03.008 [doi]
PST - ppublish
SO  - Talanta. 2018 Jul 1;184:296-306. doi: 10.1016/j.talanta.2018.03.008. Epub 2018 
      Mar 7.