PMID- 29674194
OWN - NLM
STAT- MEDLINE
DCOM- 20181023
LR  - 20181023
IS  - 2210-7797 (Electronic)
IS  - 2210-7789 (Linking)
VI  - 12
DP  - 2018 Apr
TI  - Resting-state functional connectivity in children born from gestations 
      complicated by preeclampsia: A pilot study cohort.
PG  - 23-28
LID - S2210-7789(17)30147-2 [pii]
LID - 10.1016/j.preghy.2018.02.004 [doi]
AB  - BACKGROUND: Individuals (PE-F1s) born from preeclampsia (PE)-complicated 
      pregnancies have elevated risks for cognitive impairment. Intervals of disturbed 
      maternal plasma angiokines precede clinical signs of PE. We hypothesized 
      pan-blastocyst dysregulation of angiokines underlies altered PE-F1 brain vascular 
      and neurological development. This could alter brain functional connectivity (FC) 
      patterns at rest. MATERIALS AND METHODS: Resting-state functional MRI datasets of 
      ten, matched child pairs (5 boys and 5 girls aged 7-10 years of age) from PE or 
      control pregnancies were available for study. Seed-based analysis and independent 
      component analysis (ICA) methodologies were used to assess whether differences in 
      resting-state functional connectivity (rs-FC) were present between PE-F1s and 
      controls. Bilateral amygdala, bilateral hippocampus, and medial prefrontal cortex 
      (MPFC) were selected as regions of interest (ROI) for the seed-based analysis 
      based on previous imaging differences that we reported in this set of children. 
      RESULTS: Compared to controls, PE-F1 children had increased rs-FC between the 
      right amygdala and left frontal pole, the left amygdala and bilateral frontal 
      pole, and the MPFC and precuneus. PE-F1 children additionally had decreased rs-FC 
      between the MPFC and the left occipital fusiform gyrus compared to controls. 
      CONCLUSION: These are the first reported rs-FC data for PE-F1s of any age. 
      Theysuggest that PE alters FC during human fetal brain development. Altered FC 
      may contribute to the behavioural and neurological alterations reported in 
      PE-F1s. Longitudinal MRI studies with larger sample sizes are required to confirm 
      these novel findings.
CI  - Copyright (c) 2018 International Society for the Study of Hypertension in 
      Pregnancy. Published by Elsevier B.V. All rights reserved.
FAU - Mak, Lauren E
AU  - Mak LE
AD  - Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
FAU - Croy, B Anne
AU  - Croy BA
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Kay, Vanessa
AU  - Kay V
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Reynolds, James N
AU  - Reynolds JN
AD  - Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; 
      Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada.
FAU - Ratsep, Matthew T
AU  - Ratsep MT
AD  - Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON, 
      Canada.
FAU - Forkert, Nils D
AU  - Forkert ND
AD  - Department of Radiology and Hotchkiss Brain Institute, University of Calgary, 
      Calgary, AB, Canada.
FAU - Smith, Graeme N
AU  - Smith GN
AD  - Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; 
      Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON, 
      Canada.
FAU - Paolozza, Angelina
AU  - Paolozza A
AD  - Laboratory for Infant Studies, University of Toronto Scarborough, Scarborough, 
      ON, Canada.
FAU - Stroman, Patrick W
AU  - Stroman PW
AD  - Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
FAU - Figueiro-Filho, Ernesto A
AU  - Figueiro-Filho EA
AD  - Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; 
      Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      ON, Canada; Faculty of Medicine, Federal University of Mato Grosso do Sul, 
      (FAMED-UFMS), Campo Grande, MS, Brazil. Electronic address: eaff@queensu.ca.
LA  - eng
PT  - Journal Article
DEP - 20180207
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
SB  - IM
MH  - Age Factors
MH  - *Blood Pressure
MH  - Brain/diagnostic imaging/growth & development/*physiopathology
MH  - Brain Mapping/methods
MH  - Case-Control Studies
MH  - Child
MH  - *Child Development
MH  - Child, Preschool
MH  - *Cognition
MH  - Cognition Disorders/diagnostic imaging/*etiology/physiopathology/psychology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Neural Pathways
MH  - Pilot Projects
MH  - Pre-Eclampsia/diagnosis/*physiopathology
MH  - Pregnancy
OTO - NOTNLM
OT  - Case-control studies
OT  - Functional neuroimaging
OT  - Human pregnancy
OT  - Magnetic resonance imaging
EDAT- 2018/04/21 06:00
MHDA- 2018/10/24 06:00
CRDT- 2018/04/21 06:00
PHST- 2017/07/11 00:00 [received]
PHST- 2017/11/02 00:00 [revised]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2018/10/24 06:00 [medline]
PHST- 2018/04/21 06:00 [entrez]
AID - S2210-7789(17)30147-2 [pii]
AID - 10.1016/j.preghy.2018.02.004 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2018 Apr;12:23-28. doi: 10.1016/j.preghy.2018.02.004. Epub 
      2018 Feb 7.