PMID- 29674268
OWN - NLM
STAT- MEDLINE
DCOM- 20190829
LR  - 20200306
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 102
DP  - 2018 Jul
TI  - Frequency-dependent functional connectivity of the nucleus accumbens during 
      continuous transcutaneous vagus nerve stimulation in major depressive disorder.
PG  - 123-131
LID - S0022-3956(17)30747-1 [pii]
LID - 10.1016/j.jpsychires.2017.12.018 [doi]
AB  - Transcutaneous vagus nerve stimulation (tVNS) may be a promising treatment for 
      major depressive disorder (MDD). In this exploratory study, fMRI scans were 
      acquired during continuous real or sham tVNS from 41 MDD patients. Then, all 
      patients received real or sham tVNS treatment for four weeks. We investigated the 
      functional connectivity (FC) of the nucleus accumbens (NAc) at different 
      frequency bands during real and sham tVNS and explored their associations with 
      depressive symptom changes after one month of treatment. The results revealed: 1) 
      significant positive FCs between the NAc and surrounding areas including the 
      putamen, caudate, and distinct areas of the medial prefrontal cortex (MPFC) and 
      the anterior cingulate cortex (ACC) during continuous real and sham tVNS; 2) 
      compared with sham tVNS, real tVNS increased the FC between the left NAc and 
      bilateral MPFC/rACC in the slow-5 band (0.008-0.027) and between the right NAc 
      and left insula, occipital gyrus, and right lingual/fusiform gyrum in the typical 
      low band (0.008-0.09); and 3) the FC of the NAc-MPFC/rACC during real tVNS showed 
      a negative association with Hamilton Depression Rating Scale (HAMD) score changes 
      in the real tVNS group after one month of treatment, but not in the sham group. 
      Our findings demonstrate that tVNS can modulate low frequency intrinsic FC among 
      key brain regions involved in reward and motivation processing and provide 
      insights into the brain mechanism underlying tVNS treatment of MDD.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Wang, Zengjian
AU  - Wang Z
AD  - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 
      Charlestown, MA 02129, USA; Department of Maternal and Child Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
FAU - Fang, Jiliang
AU  - Fang J
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, 
      China.
FAU - Liu, Jun
AU  - Liu J
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, 
      China.
FAU - Rong, Peijing
AU  - Rong P
AD  - Institute of Acupuncture & Moxibustion, China Academy of Chinese Medical 
      Sciences, Beijing 100700, China. Electronic address: drrongpj@163.com.
FAU - Jorgenson, Kristen
AU  - Jorgenson K
AD  - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 
      Charlestown, MA 02129, USA.
FAU - Park, Joel
AU  - Park J
AD  - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 
      Charlestown, MA 02129, USA.
FAU - Lang, Courtney
AU  - Lang C
AD  - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 
      Charlestown, MA 02129, USA.
FAU - Hong, Yang
AU  - Hong Y
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, 
      China.
FAU - Zhu, Bing
AU  - Zhu B
AD  - Institute of Acupuncture & Moxibustion, China Academy of Chinese Medical 
      Sciences, Beijing 100700, China.
FAU - Kong, Jian
AU  - Kong J
AD  - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 
      Charlestown, MA 02129, USA. Electronic address: kongj@nmr.mgh.harvard.edu.
LA  - eng
GR  - R01 AT006364/AT/NCCIH NIH HHS/United States
GR  - R01 AT008563/AT/NCCIH NIH HHS/United States
GR  - R21 AT008707/AT/NCCIH NIH HHS/United States
GR  - R61 AT009310/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20171228
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Biophysics
MH  - Brain Mapping
MH  - Cerebral Cortex/diagnostic imaging/physiopathology
MH  - Depressive Disorder, Major/*therapy
MH  - Echo-Planar Imaging
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/diagnostic imaging/*physiopathology
MH  - Nucleus Accumbens/diagnostic imaging/*physiopathology
MH  - Oxygen/blood
MH  - Psychiatric Status Rating Scales
MH  - Transcutaneous Electric Nerve Stimulation/*methods
MH  - Vagus Nerve/*physiology
PMC - PMC6005725
MID - NIHMS939974
OTO - NOTNLM
OT  - Functional connectivity
OT  - Major depressive disorder
OT  - Neuromodulation
OT  - Nucleus accumbens
OT  - Slow 5 frequency band
OT  - Transcutaneous vagus nerve stimulation
COIS- Conflict of interest J.K has a disclosure to report (holding equity in a startup 
      company (MNT)), but declare no conflict of interest.
EDAT- 2018/04/21 06:00
MHDA- 2019/08/30 06:00
PMCR- 2019/07/01
CRDT- 2018/04/21 06:00
PHST- 2017/07/03 00:00 [received]
PHST- 2017/11/20 00:00 [revised]
PHST- 2017/12/25 00:00 [accepted]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2019/08/30 06:00 [medline]
PHST- 2018/04/21 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - S0022-3956(17)30747-1 [pii]
AID - 10.1016/j.jpsychires.2017.12.018 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2018 Jul;102:123-131. doi: 10.1016/j.jpsychires.2017.12.018. 
      Epub 2017 Dec 28.