PMID- 29675246
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220216
IS  - 2041-6520 (Print)
IS  - 2041-6539 (Electronic)
IS  - 2041-6520 (Linking)
VI  - 9
IP  - 7
DP  - 2018 Feb 21
TI  - A water-soluble supramolecular complex that mimics the heme/copper 
      hetero-binuclear site of cytochrome c oxidase.
PG  - 1989-1995
LID - 10.1039/c7sc04732k [doi]
AB  - In mitochondria, cytochrome c oxidase (CcO) catalyses the reduction of oxygen 
      (O(2)) to water by using a heme/copper hetero-binuclear active site. Here we 
      report a highly efficient supramolecular approach for the construction of a 
      water-soluble biomimetic model for the active site of CcO. A tridentate 
      copper(ii) complex was fixed onto 
      5,10,15,20-tetrakis(4-sulfonatophenyl)porphinatoiron(iii) (Fe(III)TPPS) through 
      supramolecular complexation between Fe(III)TPPS and a per-O-methylated 
      beta-cyclodextrin dimer linked by a (2,2':6',2''-terpyridyl)copper(ii) complex 
      (Cu(II)TerpyCD(2)). The reduced Fe(II)TPPS/Cu(I)TerpyCD(2) complex reacted with 
      O(2) in an aqueous solution at pH 7 and 25  degrees C to form a superoxo-type 
      Fe(III)-O(2)(-)/Cu(I) complex in a manner similar to CcO. The pH-dependent 
      autoxidation of the O(2) complex suggests that water molecules gathered at the 
      distal Cu site are possibly involved in the Fe(III)-O(2)(-)/Cu(I) superoxo 
      complex in an aqueous solution. Electrochemical analysis using a rotating disk 
      electrode demonstrated the role of the FeTPPS/CuTerpyCD(2) hetero-binuclear 
      structure in the catalytic O(2) reduction reaction.
FAU - Kitagishi, Hiroaki
AU  - Kitagishi H
AUID- ORCID: 0000-0003-4682-7217
AD  - Department of Molecular Chemistry and Biochemistry , Faculty of Science and 
      Engineering , Doshisha University , Kyotanabe , Kyoto 610-0321 , Japan . Email: 
      hkitagis@mail.doshisha.ac.jp.
FAU - Shimoji, Daiki
AU  - Shimoji D
AD  - Department of Molecular Chemistry and Biochemistry , Faculty of Science and 
      Engineering , Doshisha University , Kyotanabe , Kyoto 610-0321 , Japan . Email: 
      hkitagis@mail.doshisha.ac.jp.
FAU - Ohta, Takehiro
AU  - Ohta T
AUID- ORCID: 0000-0003-4140-5293
AD  - Picobiology Institute , Graduate School of Life Science , University of Hyogo , 
      RSC-UH LP Center , Hyogo 679-5148 , Japan.
FAU - Kamiya, Ryo
AU  - Kamiya R
AD  - Department of Molecular Chemistry and Biochemistry , Faculty of Science and 
      Engineering , Doshisha University , Kyotanabe , Kyoto 610-0321 , Japan . Email: 
      hkitagis@mail.doshisha.ac.jp.
FAU - Kudo, Yasuhiro
AU  - Kudo Y
AD  - Department of Molecular Chemistry and Biochemistry , Faculty of Science and 
      Engineering , Doshisha University , Kyotanabe , Kyoto 610-0321 , Japan . Email: 
      hkitagis@mail.doshisha.ac.jp.
FAU - Onoda, Akira
AU  - Onoda A
AUID- ORCID: 0000-0002-5791-4386
AD  - Department of Applied Chemistry , Graduate School of Engineering , Osaka 
      University , 2-1 Yamadaoka , Suita 565-0871 , Japan.
FAU - Hayashi, Takashi
AU  - Hayashi T
AUID- ORCID: 0000-0002-2215-935X
AD  - Department of Applied Chemistry , Graduate School of Engineering , Osaka 
      University , 2-1 Yamadaoka , Suita 565-0871 , Japan.
FAU - Weiss, Jean
AU  - Weiss J
AUID- ORCID: 0000-0001-7753-8958
AD  - Institut de Chimie de Strasbourg , UMR 7177 , CNRS , Universite de Strasbourg , 4 
      Rue Blaise Pascal , 67000 Strasbourg , France.
FAU - Wytko, Jennifer A
AU  - Wytko JA
AD  - Institut de Chimie de Strasbourg , UMR 7177 , CNRS , Universite de Strasbourg , 4 
      Rue Blaise Pascal , 67000 Strasbourg , France.
FAU - Kano, Koji
AU  - Kano K
AD  - Department of Molecular Chemistry and Biochemistry , Faculty of Science and 
      Engineering , Doshisha University , Kyotanabe , Kyoto 610-0321 , Japan . Email: 
      hkitagis@mail.doshisha.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20180115
PL  - England
TA  - Chem Sci
JT  - Chemical science
JID - 101545951
PMC - PMC5892347
EDAT- 2018/04/21 06:00
MHDA- 2018/04/21 06:01
PMCR- 2018/01/15
CRDT- 2018/04/21 06:00
PHST- 2017/11/02 00:00 [received]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/04/21 06:00 [entrez]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2018/04/21 06:01 [medline]
PHST- 2018/01/15 00:00 [pmc-release]
AID - c7sc04732k [pii]
AID - 10.1039/c7sc04732k [doi]
PST - epublish
SO  - Chem Sci. 2018 Jan 15;9(7):1989-1995. doi: 10.1039/c7sc04732k. eCollection 2018 
      Feb 21.