PMID- 29675878
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 73
IP  - 3
DP  - 2018 Sep
TI  - Interobserver reliability of histopathological features for distinguishing 
      between cutaneous polyarteritis nodosa and superficial thrombophlebitis.
PG  - 407-416
LID - 10.1111/his.13635 [doi]
AB  - AIMS: Interobserver reliability of histopathological features in differentiation 
      between cutaneous polyarteritis nodosa (cPAN) and superficial thrombophlebitis 
      (ST) by assessment of inter-rater agreement of five histological features was 
      investigated. METHODS AND RESULTS: All sections of cPAN and ST were evaluated 
      independently by three experienced pathologists and one resident of pathology. 
      The histopathological features studied included elastic fibre distribution in the 
      vascular wall, a smooth muscle arrangement pattern, an internal elastic lamina 
      pattern, fibrinoid necrosis and luminal thrombosis. Agreement analysis was 
      performed using the kappa coefficient. Sensitivity, specificity, positive 
      predictive value (PPV), positive likelihood ratio (PLR) and 95% confidence 
      interval (95% CI) of the useful histopathological features were analysed. Of all 
      62 biopsies, 28 were cPAN and 34 were ST. Reproducibility between four observers 
      was in substantial agreement (kappa = 0.73). Elastic fibre distribution in the 
      vascular wall (kappa = 0.68), fibrinoid necrosis (kappa = 0.63), an internal elastic 
      lamina pattern (kappa = 0.51) and a smooth muscle arrangement pattern (kappa = 0.46) 
      showed high specificity and PPV for differentiating between cPAN and ST. The 
      smooth muscle arrangement pattern, internal elastic lamina pattern and elastic 
      fibre distribution in the vascular wall may be obscured when extensive 
      inflammation and necrosis occurs. CONCLUSIONS: These aforementioned 
      histopathological features are useful in differentiation between cPAN and ST. The 
      Verhoeff-van Gieson (VVG) elastic stain is an important histochemical study for 
      differentiating between cPAN and ST, particularly in cases with extensive 
      inflammation and necrosis.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Hutachuda, Parnhathai
AU  - Hutachuda P
AD  - Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Hanamornroongruang, Suchanan
AU  - Hanamornroongruang S
AD  - Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Pattanaprichakul, Penvadee
AU  - Pattanaprichakul P
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Chanyachailert, Pattriya
AU  - Chanyachailert P
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Sitthinamsuwan, Panitta
AU  - Sitthinamsuwan P
AUID- ORCID: 0000-0002-8218-5787
AD  - Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20180608
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Polyarteritis Nodosa/*diagnosis/*pathology
MH  - Reproducibility of Results
MH  - Staining and Labeling
MH  - Thrombophlebitis/*diagnosis/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - cutaneous polyarteritis nodosa
OT  - fibrinoid necrosis
OT  - superficial thrombophlebitis
OT  - thrombophlebitis
OT  - vasculitis
EDAT- 2018/04/21 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/04/21 06:00
PHST- 2017/12/21 00:00 [received]
PHST- 2018/04/13 00:00 [accepted]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/04/21 06:00 [entrez]
AID - 10.1111/his.13635 [doi]
PST - ppublish
SO  - Histopathology. 2018 Sep;73(3):407-416. doi: 10.1111/his.13635. Epub 2018 Jun 8.