PMID- 29676071
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 10
IP  - 3
DP  - 2018 May
TI  - Differences in Genetic Variations Between Treatable and Recalcitrant Atopic 
      Dermatitis in Korean.
PG  - 244-252
LID - 10.4168/aair.2018.10.3.244 [doi]
AB  - PURPOSE: Variations in barrier- or immune response-related genes are closely 
      related to the development of atopic dermatitis (AD). This study was designed to 
      identify genetic variations and clinical features to predict 'recalcitrant AD.' 
      METHODS: AD patients were classified as treatable and recalcitrant. Treatable AD 
      patients showed satisfactory clinical improvement with basic and topical 
      treatments. Recalcitrant AD patients used systemic immune-suppressants for over 4 
      weeks as they had not shown clinical improvement with basic and topical 
      treatments. The frequency of gene variations in barrier- (FLG 3321delA, FLG 
      K4022X, KLK7, SPINK 1156, SPINK 1188, SPINK 2475) and immune response- (DEFB1, 
      KDR, IL-5RA, IL-9, and IL-12RB1a, b) related genes were compared between each AD 
      group and the controls. RESULTS: Of all, 249 treatable AD and 32 recalcitrant AD 
      were identified. Heterozygous mutations (Hetero) in KLK7 was more frequent in 
      recalcitrant AD patients than treatable AD, without statistical significance. 
      Hetero in DEFB1 was more frequent in treatable AD patients. However, no other 
      significant genetic differences between treatable and recalcitrant AD was 
      observed. Instead, higher initial Eczema Area Severity Index (EASI) score, serum 
      immunoglobulin E (IgE) level, allergen specific IgE for house dust mites, and 
      family history of atopic diseases were associated with recalcitrant AD with 
      statistical significance. CONCLUSIONS: According to our study, no genetic 
      variation to predict recalcitrant AD was identified, suggesting that clinical 
      manifestation, rather than genetic variations of AD patients is more likely to be 
      an important factor in predicting the prognosis of AD. Further large-scale 
      studies on the correlation between genetic variation and recalcitrant AD are 
      needed.
CI  - Copyright (c) 2018 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Jun, Myungsoo
AU  - Jun M
AUID- ORCID: 0000-0002-5111-7386
AD  - Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, 
      Korea.
FAU - Wang, Hye Young
AU  - Wang HY
AUID- ORCID: 0000-0001-8404-2248
AD  - Optipharm, Inc., Wonju Eco Environmental Technology Center, Wonju, Korea.
FAU - Lee, Solam
AU  - Lee S
AUID- ORCID: 0000-0001-6458-9449
AD  - Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, 
      Korea.
FAU - Choi, Eunhee
AU  - Choi E
AUID- ORCID: 0000-0002-3449-0672
AD  - Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, 
      Wonju, Korea.
FAU - Lee, Hyeyoung
AU  - Lee H
AUID- ORCID: 0000-0002-9087-3096
AD  - Department of Biomedical Laboratory Science, Yonsei University College of Health 
      Sciences, Wonju, Korea.
FAU - Choi, Eung Ho
AU  - Choi EH
AUID- ORCID: 0000-0002-0148-5594
AD  - Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, 
      Korea. choieh@yonsei.ac.kr.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC5911443
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - gene
OT  - immune response
OT  - single nucleotide polymorphisms
OT  - skin barrier
COIS- There are no financial or other issues that might lead to conflict of interests.
EDAT- 2018/04/21 06:00
MHDA- 2018/04/21 06:01
PMCR- 2018/05/01
CRDT- 2018/04/21 06:00
PHST- 2017/12/03 00:00 [received]
PHST- 2018/02/14 00:00 [revised]
PHST- 2018/02/18 00:00 [accepted]
PHST- 2018/04/21 06:00 [entrez]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2018/04/21 06:01 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - 10.244 [pii]
AID - 10.4168/aair.2018.10.3.244 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2018 May;10(3):244-252. doi: 
      10.4168/aair.2018.10.3.244.