PMID- 29676228
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20240330
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Print)
IS  - 1570-159X (Linking)
VI  - 16
IP  - 7
DP  - 2018
TI  - Glaucoma Pathogenesis and Neurotrophins: Focus on the Molecular and Genetic Basis 
      for Therapeutic Prospects.
PG  - 1018-1035
LID - 10.2174/1570159X16666180419121247 [doi]
AB  - BACKGROUND: Retinal ganglion cell (RGC) degeneration is a major feature of 
      glaucoma pathology. Neuroprotective approaches that delay or halt the progression 
      of RGC loss are needed to prevent vision loss which can occur even after 
      conventional medical or surgical treatments to lower intraocular pressure. 
      OBJECTIVE: The aim of this review was to examine the progress in genetics and 
      cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC 
      dysfunction and cell death pathways in glaucoma. MATERIALS AND METHODS: Here, we 
      review the involvement of neurotrophins like brain derived neurotrophic factor 
      (BDNF) and its high affinity receptor tropomyosin receptor kinase (TrkB) in 
      glaucoma. The role of ER stress markers in human and animal retinas in health and 
      disease conditions is also discussed. Further, we analysed the literature 
      highlighting genetic linkage in the context of primary open angle glaucoma and 
      suggested mechanistic insights into potential therapeutic options relevant to 
      glaucoma management. RESULTS: The literature review of the neurobiology 
      underlying neurotrophin pathways, ER stress and gene associations provide 
      critical insights into association of RGCs death in glaucoma. Alteration in 
      signalling pathway is associated with increased risk of misfolded protein 
      aggregation in ER promoting RGC apoptosis. Several genes that are linked with 
      neurotrophin signalling pathways have been reported to be associated with 
      glaucoma pathology. CONCLUSION: Understanding genetic heterogeneity and 
      involvement of neurotrophin biology in glaucoma could help to understand the 
      complex pathophysiology of glaucoma. Identification of novel molecular targets 
      will be critical for drug development and provide neuroprotection to the RGCs and 
      optic nerve.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Chitranshi, Nitin
AU  - Chitranshi N
AD  - Faculty of Medicine and Health Sciences, Macquarie University, F10A, 2 Technology 
      Place, North Ryde, NSW 2109, Australia.
FAU - Dheer, Yogita
AU  - Dheer Y
AD  - Faculty of Medicine and Health Sciences, Macquarie University, F10A, 2 Technology 
      Place, North Ryde, NSW 2109, Australia.
FAU - Abbasi, Mojdeh
AU  - Abbasi M
AD  - Faculty of Medicine and Health Sciences, Macquarie University, F10A, 2 Technology 
      Place, North Ryde, NSW 2109, Australia.
FAU - You, Yuyi
AU  - You Y
AD  - Save Sight Institute, Sydney University, Sydney NSW 2000, Australia.
FAU - Graham, Stuart L
AU  - Graham SL
AD  - Faculty of Medicine and Health Sciences, Macquarie University, F10A, 2 Technology 
      Place, North Ryde, NSW 2109, Australia.
AD  - Save Sight Institute, Sydney University, Sydney NSW 2000, Australia.
FAU - Gupta, Vivek
AU  - Gupta V
AD  - Faculty of Medicine and Health Sciences, Macquarie University, F10A, 2 Technology 
      Place, North Ryde, NSW 2109, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Glaucoma/*genetics/*metabolism/therapy
MH  - Humans
MH  - Nerve Growth Factors/*genetics/*metabolism
PMC - PMC6120108
OTO - NOTNLM
OT  - Neurotrophins
OT  - apoptosis
OT  - endoplasmic reticulum stress
OT  - gene
OT  - glaucoma
OT  - retinal ganglion cells.
EDAT- 2018/04/21 06:00
MHDA- 2018/10/23 06:00
PMCR- 2019/02/01
CRDT- 2018/04/21 06:00
PHST- 2017/07/02 00:00 [received]
PHST- 2018/04/10 00:00 [revised]
PHST- 2018/04/18 00:00 [accepted]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/04/21 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - CN-EPUB-89844 [pii]
AID - CN-16-1018 [pii]
AID - 10.2174/1570159X16666180419121247 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2018;16(7):1018-1035. doi: 
      10.2174/1570159X16666180419121247.