PMID- 29676537 OWN - NLM STAT- MEDLINE DCOM- 20191107 LR - 20210109 IS - 1750-2659 (Electronic) IS - 1750-2640 (Print) IS - 1750-2640 (Linking) VI - 12 IP - 5 DP - 2018 Sep TI - Recovery of pulmonary functions, exercise capacity, and quality of life after pulmonary rehabilitation in survivors of ARDS due to severe influenza A (H1N1) pneumonitis. PG - 643-648 LID - 10.1111/irv.12566 [doi] AB - BACKGROUND: Acute respiratory distress syndrome (ARDS) due to severe influenza A H1N1 pneumonitis would result in impaired pulmonary functions and health-related quality of life (HRQoL) after hospital discharge. OBJECTIVES: The recovery of pulmonary functions, exercise capacity, and HRQoL in the survivors of ARDS due to 2009 pandemic influenza A H1N1 pneumonitis (H1N1-ARDS) was evaluated in a tertiary teaching hospital in northern Taiwan between May 2010 and June 2011. PATIENTS AND METHODS: Data of spirometry, total lung capacity (TLC), diffusing capacity of carbon monoxide (DL(CO) ), and 6-minute walk distance (6MWD) in the patients survived from H1N1-ARDS were collected 1, 3, and 6 months post-hospital discharge. HRQoL was evaluated with St. George respiratory questionnaire (SGRQ). RESULTS: Nine survivors of H1N1-ARDS in the study period were included. All these patients received 2 months' pulmonary rehabilitation program. Pulmonary functions and exercise capacity included TLC, forced vital capacity (FVC), forced expiratory volume in the first second (FEV(1) ), DL(CO) , and 6MWD improved from 1 to 3 months post-hospital discharge. Only TLC had further significant improvement from 3 to 6 months. HRQoL represented as the total score of SGRQ had no significant improvement in the first 3 months but improved significantly from 3 to 6 months post-discharge. CONCLUSION: The impaired pulmonary functions and exercise capacity in the survivors of H1N1-ARDS improved soon at 3 months after hospital discharge. Their quality of life had keeping improved at 6 months even though there was no further improvement of their pulmonary functions and exercise capacity. CI - (c) 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. FAU - Hsieh, Meng-Jer AU - Hsieh MJ AUID- ORCID: 0000-0002-2077-0470 AD - Department of Pulmonary and Critical Care Medicine, Chia-Yi Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Chiayi, Taiwan. AD - Department of Respiratory Therapy, School of Medicine, Chang-Gung University, Taoyuan, Taiwan. FAU - Lee, Wei-Chun AU - Lee WC AD - Department of Pulmonary and Critical Care Medicine, Chia-Yi Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Chiayi, Taiwan. FAU - Cho, Hsiu-Ying AU - Cho HY AD - Department of Respiratory Therapy, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. FAU - Wu, Meng-Fang AU - Wu MF AD - Department of Respiratory Therapy, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. FAU - Hu, Han-Chung AU - Hu HC AD - Department of Respiratory Therapy, School of Medicine, Chang-Gung University, Taoyuan, Taiwan. AD - Department of Respiratory Therapy, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. AD - Department of Pulmonary and Critical Care Medicine, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. FAU - Kao, Kuo-Chin AU - Kao KC AD - Department of Respiratory Therapy, School of Medicine, Chang-Gung University, Taoyuan, Taiwan. AD - Department of Respiratory Therapy, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. AD - Department of Pulmonary and Critical Care Medicine, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. FAU - Chen, Ning-Hung AU - Chen NH AD - Department of Respiratory Therapy, School of Medicine, Chang-Gung University, Taoyuan, Taiwan. AD - Department of Respiratory Therapy, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. AD - Department of Pulmonary and Critical Care Medicine, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. FAU - Tsai, Ying-Huang AU - Tsai YH AD - Department of Pulmonary and Critical Care Medicine, Chia-Yi Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Chiayi, Taiwan. AD - Department of Respiratory Therapy, School of Medicine, Chang-Gung University, Taoyuan, Taiwan. FAU - Huang, Chung-Chi AU - Huang CC AD - Department of Respiratory Therapy, School of Medicine, Chang-Gung University, Taoyuan, Taiwan. AD - Department of Respiratory Therapy, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. AD - Department of Pulmonary and Critical Care Medicine, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyaun, Taiwan. LA - eng PT - Journal Article PT - Observational Study DEP - 20180612 PL - England TA - Influenza Other Respir Viruses JT - Influenza and other respiratory viruses JID - 101304007 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Influenza A Virus, H1N1 Subtype/*isolation & purification MH - Influenza, Human/complications/*pathology/virology MH - Lung/*physiology MH - Male MH - Middle Aged MH - Pneumonia/complications/*pathology/virology MH - *Quality of Life MH - Respiratory Distress Syndrome/*pathology MH - *Respiratory Function Tests MH - Taiwan MH - Tertiary Care Centers MH - Time Factors MH - Treatment Outcome MH - Young Adult PMC - PMC6086854 OTO - NOTNLM OT - acute respiratory distress syndrome OT - exercise capacity OT - influenza A H1N1 OT - pulmonary function tests OT - quality of life EDAT- 2018/04/21 06:00 MHDA- 2019/11/08 06:00 PMCR- 2018/09/01 CRDT- 2018/04/21 06:00 PHST- 2018/03/28 00:00 [accepted] PHST- 2018/04/21 06:00 [pubmed] PHST- 2019/11/08 06:00 [medline] PHST- 2018/04/21 06:00 [entrez] PHST- 2018/09/01 00:00 [pmc-release] AID - IRV12566 [pii] AID - 10.1111/irv.12566 [doi] PST - ppublish SO - Influenza Other Respir Viruses. 2018 Sep;12(5):643-648. doi: 10.1111/irv.12566. Epub 2018 Jun 12.