PMID- 29677554
OWN - NLM
STAT- MEDLINE
DCOM- 20190718
LR  - 20190718
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 83
DP  - 2018 Jul
TI  - Glass -polyalkenoate cement: An alternative material for kyphoplasty in 
      osteoporotic vertebral compression fractures - An ex vivo study.
PG  - 46-51
LID - S1751-6161(18)30276-5 [pii]
LID - 10.1016/j.jmbbm.2018.03.008 [doi]
AB  - Adjacent vertebral body fracture is described as a risk after vertebroplasty and 
      kyphoplasty. It may be true that this phenomenon is caused precisely because of 
      the frequently used polymethylmethacrylate cement (PMMA), which shows a higher 
      level of stiffness than bone material and may ultimately lead to shifting stress 
      levels within the entire spine. The goal of the present study was to evaluate and 
      compare the pressure distribution in the endplate of human vertebrae after 
      kyphoplasty with PMMA and aluminum-free glass-polyalkenoate cement (gpc). For the 
      present study, 8 fresh frozen human cadaveric vertebral bodies from the 
      thoracolumbar junction were used. All vertebrae were augmented transpedicularly 
      on one side with gpc and on the other side with PMMA. A loading of 600 N, 800 N 
      and 1000 N was applied. In the data processing an individual region of interest 
      (roi) was generated for each vertebra. The following parameters were determined 
      for each roi: maximum force [N], maximum pressure [kPa], mean pressure [kPa], roi 
      area [cm(2)]. We found significantly higher mean pressure values in the areas of 
      the vertebrae augmented with PMMA, compared to the ones after augmentation with 
      gpc (p = 0.012) when applying 1000 N. In the groups with lower forces there were 
      no statistical relevant differences. The pressure distribution shows an advantage 
      for gpc. A material, which does not create load concentration onto the cranial 
      and caudal vertebral surface, could have major advantages concerning the risk of 
      adjacent vertebral fractures. Thus the results of the 1000 N loading protocol 
      suggest gpc being a possible alternative to ordinary PMMA cement, regarding its 
      influence on stiffness in kyphoplasty. These and other general aspects like 
      incorporation should be addressed and elaborated more detailed in further 
      studies.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Leschinger, Tim
AU  - Leschinger T
AD  - Center for Orthopedic and Trauma Surgery, University Medical Center, Cologne, 
      Germany; Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, 
      University of Cologne, Cologne, Germany. Electronic address: 
      tim.leschinger@uk-koeln.de.
FAU - Engel, Karsten
AU  - Engel K
AD  - Institute of Biomechanics and Orthopaedics, German Sport University Cologne, 
      Cologne, Germany.
FAU - Bruggemann, Gert Peter
AU  - Bruggemann GP
AD  - Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, University of 
      Cologne, Cologne, Germany; Institute of Biomechanics and Orthopaedics, German 
      Sport University Cologne, Cologne, Germany.
FAU - Dederer, Viktoria
AU  - Dederer V
AD  - Center for Orthopedic and Trauma Surgery, University Medical Center, Cologne, 
      Germany; Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, 
      University of Cologne, Cologne, Germany.
FAU - Neiss, Wolfram Friedrich
AU  - Neiss WF
AD  - Institute of Anatomy I, University of Cologne, Cologne, Germany.
FAU - Scheyerer, Max Joseph
AU  - Scheyerer MJ
AD  - Center for Orthopedic and Trauma Surgery, University Medical Center, Cologne, 
      Germany; Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, 
      University of Cologne, Cologne, Germany.
FAU - Muller, Lars Peter
AU  - Muller LP
AD  - Center for Orthopedic and Trauma Surgery, University Medical Center, Cologne, 
      Germany; Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, 
      University of Cologne, Cologne, Germany.
FAU - Wegmann, Kilian
AU  - Wegmann K
AD  - Center for Orthopedic and Trauma Surgery, University Medical Center, Cologne, 
      Germany; Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, 
      University of Cologne, Cologne, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180321
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Glass Ionomer Cements)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Fractures, Compression/*surgery
MH  - Glass/*chemistry
MH  - Glass Ionomer Cements/*chemistry
MH  - Humans
MH  - *Kyphoplasty
MH  - Male
MH  - Middle Aged
MH  - Osteoporotic Fractures/*surgery
MH  - Spinal Fractures/*surgery
OTO - NOTNLM
OT  - Adjacent vertebral body fracture
OT  - Aluminum-free glass-polyalkenoate cement
OT  - Kyphoplasty
OT  - PMMA
OT  - Stiffness
OT  - Vertebral osteoporotic fractures
EDAT- 2018/04/21 06:00
MHDA- 2019/07/19 06:00
CRDT- 2018/04/21 06:00
PHST- 2017/11/04 00:00 [received]
PHST- 2018/02/27 00:00 [revised]
PHST- 2018/03/05 00:00 [accepted]
PHST- 2018/04/21 06:00 [pubmed]
PHST- 2019/07/19 06:00 [medline]
PHST- 2018/04/21 06:00 [entrez]
AID - S1751-6161(18)30276-5 [pii]
AID - 10.1016/j.jmbbm.2018.03.008 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2018 Jul;83:46-51. doi: 10.1016/j.jmbbm.2018.03.008. 
      Epub 2018 Mar 21.