PMID- 29678746
OWN - NLM
STAT- MEDLINE
DCOM- 20190917
LR  - 20210509
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 142
IP  - 5
DP  - 2018 Nov
TI  - Thirdhand smoke component can exacerbate a mouse asthma model through mast cells.
PG  - 1618-1627.e9
LID - S0091-6749(18)30516-5 [pii]
LID - 10.1016/j.jaci.2018.04.001 [doi]
AB  - BACKGROUND: Thirdhand smoke (THS) represents the accumulation of secondhand smoke 
      on indoor surfaces and in dust, which, over time, can become more toxic than 
      secondhand smoke. Although it is well known that children of smokers are at 
      increased risk for asthma or asthma exacerbation if the disease is already 
      present, how exposure to THS can influence the development or exacerbation of 
      asthma remains unknown. OBJECTIVE: We investigated whether epicutaneous exposure 
      to an important component of THS, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 
      (NNK), can influence asthma pathology in a mouse model elicited by means of 
      repeated intranasal challenge with cockroach antigen (CRA). METHODS: Wild-type 
      mice, alpha7 nicotinic acetylcholine receptor (nAChR)- or mast cell (MC)-deficient 
      mice, and mice with MCs that lacked alpha7 nAChRs or were the host's sole source of 
      alpha7 nAChRs were subjected to epicutaneous NNK exposure, intranasal CRA challenge, 
      or both, and the severity of features of asthma pathology, including airway 
      hyperreactivity, airway inflammation, and airway remodeling, was assessed. 
      RESULTS: We found that alpha7 nAChRs were required to observe adverse effects of 
      epicutaneous NNK exposure on multiple features of CRA-induced asthma pathology. 
      Moreover, MC expression of alpha7 nAChRs contributed significantly to the ability of 
      epicutaneous NNK exposure to exacerbate airway hyperreactivity to methacholine, 
      airway inflammation, and airway remodeling in this model. CONCLUSION: Our results 
      show that skin exposure to NNK, a component of THS, can exacerbate multiple 
      features of a CRA-induced model of asthma in mice and define MCs as key 
      contributors to these adverse effects of NNK.
CI  - Copyright (c) 2018 American Academy of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Yu, Mang
AU  - Yu M
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, Calif; 
      Sean N. Parker Center for Allergy and Asthma Research, Stanford University School 
      of Medicine, Stanford, Calif. Electronic address: yumyu@staford.edu.
FAU - Mukai, Kaori
AU  - Mukai K
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, Calif; 
      Sean N. Parker Center for Allergy and Asthma Research, Stanford University School 
      of Medicine, Stanford, Calif.
FAU - Tsai, Mindy
AU  - Tsai M
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, Calif; 
      Sean N. Parker Center for Allergy and Asthma Research, Stanford University School 
      of Medicine, Stanford, Calif.
FAU - Galli, Stephen J
AU  - Galli SJ
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, Calif; 
      Sean N. Parker Center for Allergy and Asthma Research, Stanford University School 
      of Medicine, Stanford, Calif; Department of Microbiology and Immunology, Stanford 
      University School of Medicine, Stanford, Calif. Electronic address: 
      sgalli@stanford.edu.
LA  - eng
GR  - R01 AI070813/AI/NIAID NIH HHS/United States
GR  - R01 AR067145/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180418
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Nitrosamines)
RN  - 0 (Smoke)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 0 (alpha7 Nicotinic Acetylcholine Receptor)
RN  - 7S395EDO61 (4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
EIN - J Allergy Clin Immunol. 2021 May;147(5):1981. PMID: 33965095
MH  - Administration, Intranasal
MH  - Allergens/administration & dosage
MH  - Animals
MH  - Asthma/*immunology
MH  - Cockroaches/immunology
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Lung/drug effects/immunology
MH  - Mast Cells/*drug effects/immunology
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Nitrosamines/*toxicity
MH  - Ovalbumin/administration & dosage
MH  - Skin/*drug effects/immunology
MH  - Smoke/*adverse effects
MH  - *Tobacco Smoke Pollution
MH  - alpha7 Nicotinic Acetylcholine Receptor/genetics/*immunology
PMC - PMC6193858
MID - NIHMS961364
OTO - NOTNLM
OT  - 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
OT  - Thirdhand smoke
OT  - cockroach allergen
OT  - mast cells
OT  - alpha7 nicotinic acetylcholine receptor
EDAT- 2018/04/22 06:00
MHDA- 2019/09/19 06:00
PMCR- 2019/11/01
CRDT- 2018/04/22 06:00
PHST- 2017/05/05 00:00 [received]
PHST- 2018/03/13 00:00 [revised]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/04/22 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2018/04/22 06:00 [entrez]
PHST- 2019/11/01 00:00 [pmc-release]
AID - S0091-6749(18)30516-5 [pii]
AID - 10.1016/j.jaci.2018.04.001 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2018 Nov;142(5):1618-1627.e9. doi: 
      10.1016/j.jaci.2018.04.001. Epub 2018 Apr 18.