PMID- 29678854
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20221207
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 48
IP  - 2
DP  - 2018 Mar
TI  - The Relationship of Methylenetetrahydrofolate Reductase Gene C677T Polymorphism 
      and Ischemic Stroke in Chinese Han Population.
PG  - 242-247
AB  - BACKGROUND: The purpose of this study was to investigate the relationship of 
      methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic 
      stroke Large-artery atherosclerosis (LAA) and Small-artery occlusion (SAO) 
      subtypes in Chinese Han Population. MATERIALS AND METHODS: One hundred and thirty 
      LAA patients and one hundred and fifty-nine SAO patients data were prospectively 
      collected. The control group was one hundred and ninety-eight subjects from the 
      Medical Examination Center in the same period. Plasma homocysteine (Hcy) levels 
      were determined by a double reagent enzymatic cycling method. The genotypes of 
      MTHFR polymorphism (C677T) were determined using polymerase chain 
      reaction-restriction fragment length polymorphism. RESULTS: As compared with the 
      controls, hypertension prevalence, smoking consumption ratio were significantly 
      higher, plasma Hcy levels increased significantly, plasma high-density 
      lipoprotein cholesterol levels were significantly reduced in LAA and SAO groups 
      (P<0.05 for each). Elevated plasma Hcy levels were associated with MTHFR C677T 
      polymorphism (P<0.01). The frequency of C/T+T/T genotypes and T allele in LAA and 
      SAO groups was significantly higher than those in control groups (P<0.01). 
      CONCLUSIONS: The present study suggests that hypertension, smoking, decreasing 
      plasma high-density lipoprotein cholesterol levels and hyperhomocysteinemia 
      (HHcy) are independent risk factors for LAA and SAO subtypes of ischemic stroke 
      in Chinese Han Population. The MTHFR gene C677T C/T+T/T genotypes and T allele 
      increases the risk of LAA and SAO subtypes of ischemic stroke.
CI  - (c) 2018 by the Association of Clinical Scientists, Inc.
FAU - Mao, Xinlei
AU  - Mao X
AD  - Department of Neurology, Wenzhou Central Hospital & Dingli Clinical Institute of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China 57078692@qq.com.
FAU - Han, Liya
AU  - Han L
AD  - Department of Neurology, Wenzhou Central Hospital & Dingli Clinical Institute of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Brain Ischemia/complications
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Homocysteine/blood
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Stroke/blood/etiology/*genetics
OTO - NOTNLM
OT  - Ischemic stroke
OT  - gene polymorphism
OT  - homocysteine
OT  - methylenetetrahydrofolate reductase
EDAT- 2018/04/22 06:00
MHDA- 2018/09/12 06:00
CRDT- 2018/04/22 06:00
PHST- 2018/04/22 06:00 [entrez]
PHST- 2018/04/22 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
AID - 48/2/242 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2018 Mar;48(2):242-247.