PMID- 29679637
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20191130
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 71
DP  - 2018 Jul
TI  - Recent stimulant use and leukocyte gene expression in methamphetamine users with 
      treated HIV infection.
PG  - 108-115
LID - S0889-1591(18)30090-4 [pii]
LID - 10.1016/j.bbi.2018.04.004 [doi]
AB  - Stimulant use may accelerate HIV disease progression through biological and 
      behavioral pathways. However, scant research with treated HIV-positive persons 
      has examined stimulant-associated alterations in pathophysiologic processes 
      relevant to HIV pathogenesis. In a sample of 55 HIV-positive, 
      methamphetamine-using sexual minority men with a viral load less than 
      200 copies/mL, we conducted RNA sequencing to examine patterns of leukocyte gene 
      expression in participants who had a urine sample that was reactive for 
      stimulants (n = 27) as compared to those who tested non-reactive (n = 28). 
      Results indicated differential expression of 32 genes and perturbation of 168 
      pathways in recent stimulant users. We observed statistically significant 
      differential expression of single genes previously associated with HIV latency, 
      cell cycle regulation, and immune activation in recent stimulant users (false 
      discovery rate p < 0.10). Pathway analyses indicated enrichment for genes 
      associated with inflammation, innate immune activation, neuroendocrine hormone 
      regulation, and neurotransmitter synthesis. Recent stimulant users displayed 
      concurrent elevations in plasma levels of tumor necrosis factor - alpha (TNF-alpha) 
      but not interleukin 6 (IL-6). Further research is needed to examine the 
      bio-behavioral mechanisms whereby stimulant use may contribute to HIV persistence 
      and disease progression.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Carrico, Adam W
AU  - Carrico AW
AD  - University of Miami School of Medicine, United States. Electronic address: 
      a.carrico@miami.edu.
FAU - Flentje, Annesa
AU  - Flentje A
AD  - University of California, San Francisco School of Nursing, United States.
FAU - Kober, Kord
AU  - Kober K
AD  - University of California, San Francisco School of Nursing, United States.
FAU - Lee, Sulggi
AU  - Lee S
AD  - University of California, San Francisco School of Medicine, United States.
FAU - Hunt, Peter
AU  - Hunt P
AD  - University of California, San Francisco School of Medicine, United States.
FAU - Riley, Elise D
AU  - Riley ED
AD  - University of California, San Francisco School of Medicine, United States.
FAU - Shoptaw, Steven
AU  - Shoptaw S
AD  - University of California, Los Angeles School of Medicine, United States.
FAU - Flowers, Elena
AU  - Flowers E
AD  - University of California, San Francisco School of Nursing, United States; 
      University of California, San Francisco Institute for Human Genetics, United 
      States.
FAU - Dilworth, Samantha E
AU  - Dilworth SE
AD  - University of California, San Francisco School of Medicine, United States.
FAU - Pahwa, Savita
AU  - Pahwa S
AD  - University of Miami School of Medicine, United States.
FAU - Aouizerat, Bradley E
AU  - Aouizerat BE
AD  - New York University College of Dentistry Bluestone Center for Clinical Research, 
      United States.
LA  - eng
GR  - UL1 TR001872/TR/NCATS NIH HHS/United States
GR  - K23 GM112526/GM/NIGMS NIH HHS/United States
GR  - K24 DA039780/DA/NIDA NIH HHS/United States
GR  - P30 MH058107/MH/NIMH NIH HHS/United States
GR  - S10 OD018174/OD/NIH HHS/United States
GR  - P30 AI073961/AI/NIAID NIH HHS/United States
GR  - P30 AI027763/AI/NIAID NIH HHS/United States
GR  - K23 DA039800/DA/NIDA NIH HHS/United States
GR  - T32 DA007250/DA/NIDA NIH HHS/United States
GR  - R01 DA033854/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20180418
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 44RAL3456C (Methamphetamine)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Adult
MH  - Cocaine/adverse effects/metabolism
MH  - Disease Progression
MH  - Gene Expression/drug effects/genetics
MH  - HIV/drug effects/pathogenicity
MH  - HIV Infections/complications/*immunology/physiopathology
MH  - HIV Seropositivity/metabolism
MH  - Humans
MH  - Interleukin-6/analysis/blood
MH  - Leukocytes/*drug effects
MH  - Male
MH  - Methamphetamine/metabolism/pharmacology
MH  - Middle Aged
MH  - Sequence Analysis, RNA
MH  - Tumor Necrosis Factor-alpha/analysis/blood/drug effects
MH  - Viral Load/*drug effects
PMC - PMC6003871
MID - NIHMS962687
OTO - NOTNLM
OT  - Cocaine
OT  - Gene expression
OT  - HIV
OT  - Immune activation
OT  - Inflammation
OT  - Methamphetamine
OT  - Reservoir
EDAT- 2018/04/22 06:00
MHDA- 2019/07/16 06:00
PMCR- 2019/07/01
CRDT- 2018/04/22 06:00
PHST- 2017/12/20 00:00 [received]
PHST- 2018/03/30 00:00 [revised]
PHST- 2018/04/04 00:00 [accepted]
PHST- 2018/04/22 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2018/04/22 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - S0889-1591(18)30090-4 [pii]
AID - 10.1016/j.bbi.2018.04.004 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2018 Jul;71:108-115. doi: 10.1016/j.bbi.2018.04.004. Epub 2018 
      Apr 18.