PMID- 29679808
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20180925
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 167
DP  - 2018 Jul 1
TI  - beta-tricalcium phosphate composite ceramics with high compressive strength, 
      enhanced osteogenesis and inhibited osteoclastic activities.
PG  - 318-327
LID - S0927-7765(18)30238-8 [pii]
LID - 10.1016/j.colsurfb.2018.04.028 [doi]
AB  - beta-tricalcium phosphate (beta-TCP) is well known as a resorbable bone repair material 
      due to its inherent excellent biocompatibility and osteoconductivity. However, 
      beta-TCP is encountered with osteostimulation-deficiency and poor mechanical 
      strength because of poor sinterability. Herein, we prepared novel beta-TCP composite 
      ceramics (TCP/SPGs) by introducing strontium-containing phosphate-based glass 
      (SPG; 45P(2)O(5)-32SrO-23Na(2)O) as sintering additive. The SPG helped to achieve 
      efficient liquid-phase sintering of beta-TCP at 1100  degrees C. The compressive strength of 
      TCP/SPGs with 15 wt.% SPG (TCP/SPG15) was 2.65 times as high as that of plain 
      beta-TCP ceramic. The SPG reacted with beta-TCP, and the Sr(2+) and Na(2+) from SPG 
      replaced Ca(2+) in the lattice structure of beta-TCP, enabling the sustained release 
      of strontium from TCP/SPGs. In vitro cytological test indicated that TCP/SPGs 
      with certain amount of SPG were highly biocompatible, and noticeably promoted 
      osteogenesis, and inhibited osteoclastic activities. Our results suggested that 
      the TCP/SPG15 might be potential high-strength bone grafts used for bone defect 
      repair, especially in the osteoporotic condition.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Tian, Ye
AU  - Tian Y
AD  - School of Electromechanical Engineering, Guangdong University of Technology, 
      Guangzhou, 510006, People's Republic of China.
FAU - Lu, Teliang
AU  - Lu T
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou, 510641, People's Republic of China.
FAU - He, Fupo
AU  - He F
AD  - School of Electromechanical Engineering, Guangdong University of Technology, 
      Guangzhou, 510006, People's Republic of China. Electronic address: 
      fphe@gdut.edu.cn.
FAU - Xu, Yubin
AU  - Xu Y
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou, 510641, People's Republic of China.
FAU - Shi, Haishan
AU  - Shi H
AD  - College of Chemistry and Materials, Jinan University, Guangzhou, 510632, People's 
      Republic of China.
FAU - Shi, Xuetao
AU  - Shi X
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou, 510641, People's Republic of China.
FAU - Zuo, Fei
AU  - Zuo F
AD  - School of Electromechanical Engineering, Guangdong University of Technology, 
      Guangzhou, 510006, People's Republic of China.
FAU - Wu, Shanghua
AU  - Wu S
AD  - School of Electromechanical Engineering, Guangdong University of Technology, 
      Guangzhou, 510006, People's Republic of China.
FAU - Ye, Jiandong
AU  - Ye J
AD  - School of Materials Science and Engineering, South China University of 
      Technology, Guangzhou, 510641, People's Republic of China. Electronic address: 
      jdye@scut.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180413
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Calcium Phosphates)
RN  - 0 (beta-tricalcium phosphate)
SB  - IM
MH  - Animals
MH  - Calcium Phosphates/chemistry/*pharmacology
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Ceramics/chemistry/*pharmacology
MH  - Compressive Strength
MH  - Mice
MH  - Osteoclasts/*drug effects/metabolism
MH  - Osteogenesis/*drug effects
MH  - RAW 264.7 Cells
MH  - Structure-Activity Relationship
OTO - NOTNLM
OT  - Biological behavior
OT  - Bone graft
OT  - Calcium phosphate
OT  - Compressive strength
OT  - Strontium
EDAT- 2018/04/22 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/04/22 06:00
PHST- 2018/01/09 00:00 [received]
PHST- 2018/03/20 00:00 [revised]
PHST- 2018/04/12 00:00 [accepted]
PHST- 2018/04/22 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/04/22 06:00 [entrez]
AID - S0927-7765(18)30238-8 [pii]
AID - 10.1016/j.colsurfb.2018.04.028 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2018 Jul 1;167:318-327. doi: 
      10.1016/j.colsurfb.2018.04.028. Epub 2018 Apr 13.