PMID- 29681219
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181105
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 40
IP  - 8
DP  - 2018 Aug
TI  - Antidepressant-like effects of embelin and its possible mechanisms of action in 
      chronic unpredictable stress-induced mice.
PG  - 666-676
LID - 10.1080/01616412.2018.1460705 [doi]
AB  - Objectives Embelin, a principal active constituent of embelin ribes burm, has 
      good therapeutic effects on various diseases. To explore the effects and 
      underlying mechanisms of embelin on depression, we made a preliminary study to 
      clarify this issue. Methods We first used chronic unpredictable stress (CUS) to 
      construct the model of depression in mice. Then, we determined the effects of 
      embelin on CUS-induced behavioral dysfunction using open field test, sucrose 
      preference test, tail suspension test and forced swimming test. Furthermore, we 
      used the biological experiments to evaluate the changes of brain-derived 
      neurotrophic factor (BDNF), oxidative stress, neuronal inflammation and the 
      hypothalamic pituitary adrenal (HPA) axis after embelin treatment. Results The 
      behavioral tests indicated embelin indeed had efficient antidepressant effects. 
      Moreover, enhanced BDNF expression, decreased oxidative stress markers (TBARS, 
      nitric oxide) activities, elevated antioxidants (total thiol, catalase) 
      expression, decreased pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2) 
      expression and normalized the HPA axis activity were found after embelin 
      treatment in CUS-induced mice. Hence, the results of biological experiments 
      confirmed the antidepressant-like effects of embelin. Discussion These results 
      indicated that embelin can effectively suppress CUS-induced depressive-like 
      behaviors through increasing BDNF expression, preventing brain from oxidative 
      stress and neuronal inflammation, and normalizing the HPA activity.
FAU - Wang, Bailing
AU  - Wang B
AD  - a Department of Geriatric Psychiatry , Qingdao Mental Health Center , Qingdao , 
      China.
FAU - Chen, Xiaoqin
AU  - Chen X
AD  - b Department of Psychosis VI , Qingdao Mental Health Center , Qingdao , China.
FAU - Zhou, Tiantian
AU  - Zhou T
AD  - a Department of Geriatric Psychiatry , Qingdao Mental Health Center , Qingdao , 
      China.
FAU - Wang, Xiaoying
AU  - Wang X
AD  - c Department of Special Inspection , Qingdao Mental Health Center , Qingdao , 
      China.
LA  - eng
PT  - Journal Article
DEP - 20180421
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Antidepressive Agents)
RN  - 0 (Benzoquinones)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - SHC6U8F5ER (embelin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Benzoquinones/*pharmacology
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Chronic Disease
MH  - Depressive Disorder/*drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Inflammation/drug therapy/metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Oxidative Stress/drug effects/physiology
MH  - Random Allocation
MH  - Stress, Psychological/drug therapy/metabolism
MH  - Uncertainty
OTO - NOTNLM
OT  - BDNF
OT  - Embelin
OT  - HPA axis
OT  - chronic unpredictable stress
OT  - depression
OT  - neuronal inflammation
OT  - oxidative stress
EDAT- 2018/04/24 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/04/24 06:00
PHST- 2018/04/24 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/04/24 06:00 [entrez]
AID - 10.1080/01616412.2018.1460705 [doi]
PST - ppublish
SO  - Neurol Res. 2018 Aug;40(8):666-676. doi: 10.1080/01616412.2018.1460705. Epub 2018 
      Apr 21.