PMID- 29681594
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20180926
IS  - 1881-1736 (Electronic)
IS  - 0030-154X (Linking)
VI  - 94
IP  - 3
DP  - 2017
TI  - Postnatal changes of interleukin-18 receptor immunoreactivity in neurons of the 
      retrosplenial cortex in wild-type and interleukin-18 knock out mice.
PG  - 93-99
LID - 10.2535/ofaj.94.93 [doi]
AB  - Interleukin-18 (IL-18), which is involved in the inflammatory response, is also 
      found in the cerebral cortex. IL-18 receptor-immunoreactive (IL-18R-ir) neurons 
      are present in layer V of the retrosplenial cortex (RSC). In the adult IL-18 
      knock out (KO) mice, no IL-18R-ir neurons but many degenerated neurons are 
      present in layer V of the RSC, suggesting that any changes in the neurons of 
      layer V have occurred during postnatal development. We examined changes of IL-18R 
      expression during postnatal development. In the wild-type mice, many IL-18R-ir 
      neurons were present in layers II, III and VI of the RSC in 2-week-old mice, 
      whereas they were sparsely observed in only layer III in 3-week-old mice. No 
      IL-18R-ir neurons were present in 4- and 5-week-old mice. In older than 
      6-week-old mice, many IL-18R-ir neurons were present in layers V and VI. The 
      IL-18KO mice showed IL-18R-ir neurons in layers II, III and VI at 2-weeks-old, 
      and a few in layer III at 3-week-old mice, similar to that in the wild-type mice. 
      No IL-18R-ir neurons were found in mice older than 4 weeks of age. Thus, IL-18 or 
      IL-18R seem to be involved in the construction of neural circuits corresponding 
      to events after 3-weeks of age.
FAU - Hayakawa, Tetsu
AU  - Hayakawa T
AD  - Laboratory of Tumor Immunology and Cell Therapy Hyogo College of Medicine 
      Mukogawa.
FAU - Hata, Masaki
AU  - Hata M
AD  - Laboratory of Tumor Immunology and Cell Therapy Hyogo College of Medicine 
      Mukogawa.
FAU - Kuwahara-Otani, Sachi
AU  - Kuwahara-Otani S
AD  - Department of Anatomy Hyogo College of Medicine Mukogawa.
FAU - Yagi, Hideshi
AU  - Yagi H
AD  - Department of Anatomy Hyogo College of Medicine Mukogawa.
FAU - Okamura, Haruki
AU  - Okamura H
AD  - Laboratory of Tumor Immunology and Cell Therapy Hyogo College of Medicine 
      Mukogawa.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Okajimas Folia Anat Jpn
JT  - Okajimas folia anatomica Japonica
JID - 0401014
RN  - 0 (Receptors, Interleukin-18)
SB  - IM
MH  - Animals
MH  - Cerebral Cortex/*cytology/*growth & development/metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neurons/metabolism
MH  - Receptors, Interleukin-18/*metabolism
OTO - NOTNLM
OT  - IL-18 receptor
OT  - cerebral cortex
OT  - cytokines
OT  - development
OT  - immunohistochemistry
OT  - laminar distribution
EDAT- 2017/01/01 00:00
MHDA- 2018/09/27 06:00
CRDT- 2018/04/24 06:00
PHST- 2018/04/24 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
AID - 10.2535/ofaj.94.93 [doi]
PST - ppublish
SO  - Okajimas Folia Anat Jpn. 2017;94(3):93-99. doi: 10.2535/ofaj.94.93.