PMID- 29681955
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1731-5530 (Print)
IS  - 1897-4252 (Electronic)
IS  - 1731-5530 (Linking)
VI  - 15
IP  - 1
DP  - 2018 Mar
TI  - Ropivacaine has no advantage over bupivacaine in thoracic epidural analgesia for 
      patients with pectus excavatum undergoing the Nuss procedure - a single blind 
      randomized clinical trial comparing efficacy and safety.
PG  - 5-9
LID - 10.5114/kitp.2018.74668 [doi]
AB  - INTRODUCTION: Pectus excavatum repair (Nuss procedure) is a painful procedure 
      requiring effective postoperative analgesia. AIM: To establish whether thoracic 
      epidural analgesia with ropivacaine is non-inferior to epidural analgesia with 
      bupivacaine following the Nuss procedure in children. MATERIAL AND METHODS: The 
      prospective, randomized, controlled, single blind study included 81 children. 
      Computer-generated random numbers were used to allocate treatment. All children 
      received general anesthesia. Intraoperative and postoperative analgesia was 
      achieved with either 0.5% and 0.1% ropivacaine (group R) or 0.375% and 0.0625% 
      bupivacaine (group B). The Numeric Rating Scale (NRS) and the Prince Henry 
      Hospital Pain Score (PHHPS) were used to assess postoperative pain directly after 
      and 1, 8, 20 and 24 hours after awakening from general anesthesia. NRS scores of 
      more than 2 and a PHHPS score of more than 1 were considered as pain requiring 
      intervention. Hemodynamic stability and side effects were also compared between 
      the groups. RESULTS: The durations of the procedure and extubation times in 
      groups R and B were similar (59 +/-7 vs. 56 +/-10 minutes and 9 +/-5 vs. 10 +/-5 minutes, 
      respectively). Pain scores requiring intervention were below 10% and were 
      recorded with similar frequency in both groups, except for one difference in the 
      PHHPS score in favor of group R after 24 hours (12% vs. 40%, p < 0.05). The 
      frequency of side effects and hemodynamic stability were similar in both groups. 
      CONCLUSIONS: 0.1% epidural ropivacaine has no advantage over 0.0625% epidural 
      bupivacaine for pectus excavatum repair in children.
FAU - Walaszczyk, Malgorzata
AU  - Walaszczyk M
AD  - Department of Anesthesiology and Intensive Therapy, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Wiench, Rafal
AU  - Wiench R
AD  - Department of Conservative Dentistry with Endodontics, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Copik, Maja
AU  - Copik M
AD  - Department of Anesthesiology and Intensive Therapy, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Karpe, Jacek
AU  - Karpe J
AD  - Department of Anesthesiology and Intensive Therapy, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Lowicka, Malgorzata
AU  - Lowicka M
AD  - Department of Cardiac Anesthesia and Intensive Therapy, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Pioro, Anna
AU  - Pioro A
AD  - Department of Cardiac Anesthesia and Intensive Therapy, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Knapik, Piotr
AU  - Knapik P
AD  - Department of Cardiac Anesthesia and Intensive Therapy, Medical University of 
      Silesia, Zabrze, Poland.
FAU - Misiolek, Hanna
AU  - Misiolek H
AD  - Department of Anesthesiology and Intensive Therapy, Medical University of 
      Silesia, Zabrze, Poland.
LA  - eng
PT  - Journal Article
DEP - 20180328
PL  - Poland
TA  - Kardiochir Torakochirurgia Pol
JT  - Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic 
      surgery
JID - 101279148
PMC - PMC5907610
OTO - NOTNLM
OT  - Nuss procedure
OT  - bupivacaine
OT  - ropivacaine
OT  - thoracic epidural
EDAT- 2018/04/24 06:00
MHDA- 2018/04/24 06:01
PMCR- 2018/03/01
CRDT- 2018/04/24 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/02/03 00:00 [accepted]
PHST- 2018/04/24 06:00 [entrez]
PHST- 2018/04/24 06:00 [pubmed]
PHST- 2018/04/24 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 32366 [pii]
AID - 10.5114/kitp.2018.74668 [doi]
PST - ppublish
SO  - Kardiochir Torakochirurgia Pol. 2018 Mar;15(1):5-9. doi: 10.5114/kitp.2018.74668. 
      Epub 2018 Mar 28.