PMID- 29682561
OWN - NLM
STAT- MEDLINE
DCOM- 20180920
LR  - 20220120
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2018
DP  - 2018
TI  - Anti-Inflammatory Effect of Geniposide on Osteoarthritis by Suppressing the 
      Activation of p38 MAPK Signaling Pathway.
PG  - 8384576
LID - 10.1155/2018/8384576 [doi]
LID - 8384576
AB  - It has been suggested that the activation of the p38 mitogen activated protein 
      kinases (MAPKs) signaling pathway plays a significant role in the progression of 
      OA by leading to the overexpression of proinflammatory cytokines, chemokines, and 
      signaling enzymes in human osteoarthritis chondrocytes. However, most p38 MAPK 
      inhibitors applied for OA have been thought to be limited due to their potential 
      long-term toxicities. Geniposide (GE), an iridoid glycoside purified from the 
      fruit of the herb, has been widely used in traditional medicine for the treatment 
      of a variety of chronic inflammatory diseases. In this study, we evaluated the 
      inhibition effect of geniposide on the inflammatory progression of the surgically 
      induced osteoarthritis and whether the protective effect of geniposide on OA is 
      related to the inhibition of the p38 MAPK signaling pathway. In vitro, geniposide 
      attenuated the expression of inflammatory cytokines including interleukin-1 
      (IL-1), tumor necrosis factor (TNF-alpha), and nitric oxide (NO) production as well 
      as matrix metalloproteinase- (MMP-) 13 in chondrocytes isolated from surgically 
      induced rabbit osteoarthritis model. Additionally, geniposide markedly suppressed 
      the expression of IL-1, TNF-alpha, NO, and MMP-13 in the synovial fluid from the 
      rabbits with osteoarthritis. More importantly, our results clearly demonstrated 
      that the inhibitory effect of geniposide on surgery-induced expression of 
      inflammatory mediators in osteoarthritis was closely associated with the 
      suppression of the p38 MAPK signaling pathways. Our study demonstrates that 
      geniposide may have therapeutic potential to serve as an alternative agent for 
      the p38 MAPK inhibition for the treatment of OA due to its inherent features of 
      biological activities and low toxicity as a traditional Chinese medicine.
FAU - Chen, Yuan
AU  - Chen Y
AD  - Department of Emergency and ICU, The First Clinical Medical College, China Three 
      Gorges University, Yichang, Hubei 443002, China.
FAU - Shou, Kangquan
AU  - Shou K
AUID- ORCID: 0000-0001-7759-9902
AD  - Department of Orthopaedics, The First Clinical Medical College, China Three 
      Gorges University, Yichang, Hubei 443002, China.
FAU - Gong, Chunlong
AU  - Gong C
AD  - Department of Orthopaedics, The First Clinical Medical College, China Three 
      Gorges University, Yichang, Hubei 443002, China.
FAU - Yang, Huarui
AU  - Yang H
AD  - Department of Orthopaedics, The First Clinical Medical College, China Three 
      Gorges University, Yichang, Hubei 443002, China.
FAU - Yang, Yi
AU  - Yang Y
AD  - Department of Orthopaedics, The First Clinical Medical College, China Three 
      Gorges University, Yichang, Hubei 443002, China.
FAU - Bao, Tongzhu
AU  - Bao T
AUID- ORCID: 0000-0003-1585-356X
AD  - Department of Orthopaedics, The First Clinical Medical College, China Three 
      Gorges University, Yichang, Hubei 443002, China.
LA  - eng
PT  - Journal Article
DEP - 20180226
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Iridoids)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 145295QLXY (geniposide)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
EIN - Biomed Res Int. 2022 Jan 10;2022:9814323. PMID: 35047642
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Chondrocytes/drug effects/metabolism
MH  - Inflammation/drug therapy/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Iridoids/*pharmacology
MH  - Matrix Metalloproteinases/metabolism
MH  - Nitric Oxide/metabolism
MH  - Osteoarthritis/*drug therapy/metabolism
MH  - Rabbits
MH  - Signal Transduction/*drug effects
MH  - Synovial Fluid/drug effects/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
PMC - PMC5846349
EDAT- 2018/04/24 06:00
MHDA- 2018/09/21 06:00
PMCR- 2018/02/26
CRDT- 2018/04/24 06:00
PHST- 2017/09/28 00:00 [received]
PHST- 2018/01/02 00:00 [revised]
PHST- 2018/01/15 00:00 [accepted]
PHST- 2018/04/24 06:00 [entrez]
PHST- 2018/04/24 06:00 [pubmed]
PHST- 2018/09/21 06:00 [medline]
PHST- 2018/02/26 00:00 [pmc-release]
AID - 10.1155/2018/8384576 [doi]
PST - epublish
SO  - Biomed Res Int. 2018 Feb 26;2018:8384576. doi: 10.1155/2018/8384576. eCollection 
      2018.