PMID- 29682569
OWN - NLM
STAT- MEDLINE
DCOM- 20180920
LR  - 20220408
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2018
DP  - 2018
TI  - Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation.
PG  - 9171905
LID - 10.1155/2018/9171905 [doi]
LID - 9171905
AB  - Intestine is always exposed to external environment and intestinal microorganism; 
      thus it is more sensitive to dysfunction and dysbiosis, leading to intestinal 
      inflammation, such as inflammatory bowel disease (IBD), irritable bowel syndrome 
      (IBS), and diarrhea. An increasing number of studies indicate that dietary amino 
      acids play significant roles in preventing and treating intestinal inflammation. 
      The review aims to summarize the functions and signaling mechanisms of amino 
      acids in intestinal inflammation. Amino acids, including essential amino acids 
      (EAAs), conditionally essential amino acids (CEAAs), and nonessential amino acids 
      (NEAAs), improve the functions of intestinal barrier and expressions of 
      anti-inflammatory cytokines and tight junction proteins but decrease oxidative 
      stress and the apoptosis of enterocytes as well as the expressions of 
      proinflammatory cytokines in the intestinal inflammation. The functions of amino 
      acids are associated with various signaling pathways, including mechanistic 
      target of rapamycin (mTOR), inducible nitric oxide synthase (iNOS), 
      calcium-sensing receptor (CaSR), nuclear factor-kappa-B (NF-kappaB), 
      mitogen-activated protein kinase (MAPK), nuclear erythroid-related factor 2 
      (Nrf2), general controlled nonrepressed kinase 2 (GCN2), and 
      angiotensin-converting enzyme 2 (ACE2).
FAU - He, Fang
AU  - He F
AD  - College of Animal Science and Technology, Southwest University, Chongqing 400716, 
      China.
AD  - College of Animal Science, South China Agricultural University, Guangzhou 510642, 
      China.
FAU - Wu, Chenlu
AU  - Wu C
AUID- ORCID: 0000-0002-7435-3883
AD  - College of Animal Science and Technology, Southwest University, Chongqing 400716, 
      China.
FAU - Li, Pan
AU  - Li P
AD  - College of Animal Science and Technology, Southwest University, Chongqing 400716, 
      China.
FAU - Li, Nengzhang
AU  - Li N
AUID- ORCID: 0000-0002-3938-2363
AD  - College of Animal Science and Technology, Southwest University, Chongqing 400716, 
      China.
FAU - Zhang, Dong
AU  - Zhang D
AD  - College of Veterinary Medicine, Yangzhou University, 48 Wenhui East Road, 
      Yangzhou, Jiangsu 225009, China.
FAU - Zhu, Quoqiang
AU  - Zhu Q
AD  - College of Veterinary Medicine, Yangzhou University, 48 Wenhui East Road, 
      Yangzhou, Jiangsu 225009, China.
FAU - Ren, Wenkai
AU  - Ren W
AUID- ORCID: 0000-0002-8145-8907
AD  - College of Animal Science, South China Agricultural University, Guangzhou 510642, 
      China.
FAU - Peng, Yuanyi
AU  - Peng Y
AUID- ORCID: 0000-0002-5572-9945
AD  - College of Animal Science and Technology, Southwest University, Chongqing 400716, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180226
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Amino Acids)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Humans
MH  - Inflammation/drug therapy/*metabolism
MH  - Intestinal Mucosa/*metabolism
MH  - Intestines/drug effects
MH  - Signal Transduction/drug effects/*physiology
PMC - PMC5846438
EDAT- 2018/04/24 06:00
MHDA- 2018/09/21 06:00
PMCR- 2018/02/26
CRDT- 2018/04/24 06:00
PHST- 2017/09/30 00:00 [received]
PHST- 2017/11/30 00:00 [revised]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/04/24 06:00 [entrez]
PHST- 2018/04/24 06:00 [pubmed]
PHST- 2018/09/21 06:00 [medline]
PHST- 2018/02/26 00:00 [pmc-release]
AID - 10.1155/2018/9171905 [doi]
PST - epublish
SO  - Biomed Res Int. 2018 Feb 26;2018:9171905. doi: 10.1155/2018/9171905. eCollection 
      2018.