PMID- 29682674
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20191210
IS  - 1741-0444 (Electronic)
IS  - 0140-0118 (Linking)
VI  - 56
IP  - 10
DP  - 2018 Oct
TI  - A validation study of a dedicated software for an automated in vivo dosimetry 
      control in radiotherapy.
PG  - 1939-1947
LID - 10.1007/s11517-018-1822-3 [doi]
AB  - In vivo dosimetry (IVD) is the last step of a radiotherapy quality control 
      program aimed to ensure that the dose delivered is in agreement with that 
      prescribed. IVD procedures based on single detectors are time-consuming and 
      impossible to use for the modern radiotherapy techniques, based on static or 
      kinetic beams (modulated in intensity fluence); this means that more efficient 
      and practical methods are highly recommended. The practical method SOFTDISO, 
      based on the use of electronic portal image device (EPID), provides two tests (i) 
      the R ratio between the reconstructed and the planned isocenter doses to verify 
      an agreement within 5% and (ii) the gamma-analysis of the EPID images, to verify 
      gamma% >/= 90% and gamma(mean) </= 0.4. This paper reports the results of 11,357 IVD tests 
      carried out for 823 patients treated by three-dimensional conformal radiation 
      therapy and volumetric modulated arc therapy techniques. In particular, the dose 
      disagreements are reported distinguishing two kinds of causes, those of (i) class 
      1 that includes the errors due to inadequate quality controls and (ii) the class 
      2, due to patient morphological changes. About the tests out of tolerance, 6% 
      were by VMAT and 21% by 3DCRT, but taking into account the only class 1 of 
      errors, i.e., removing the causes of class 2, only 7% of patients examined 
      presented at least one of the three mean indexes out of tolerance. The workload 
      for IVD on 9 patients/day per linac is about 52 min/day but recently, a new 
      automated SOFTDISO version has been implemented to reduce the time to about 
      34 min/day.
FAU - Piermattei, A
AU  - Piermattei A
AD  - Istituto di Fisica, Universita Cattolica del Sacro Cuore (UCSC), Rome, Italy.
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
FAU - Greco, F
AU  - Greco F
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy. francesca.greco@policlinicogemelli.it.
FAU - Grusio, M
AU  - Grusio M
AD  - Istituto di Fisica, Universita Cattolica del Sacro Cuore (UCSC), Rome, Italy.
FAU - Menna, S
AU  - Menna S
AD  - Istituto di Fisica, Universita Cattolica del Sacro Cuore (UCSC), Rome, Italy.
FAU - Azario, L
AU  - Azario L
AD  - Istituto di Fisica, Universita Cattolica del Sacro Cuore (UCSC), Rome, Italy.
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
FAU - Stimato, G
AU  - Stimato G
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
FAU - Placidi, E
AU  - Placidi E
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
FAU - Teodoli, S
AU  - Teodoli S
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
FAU - Cilla, S
AU  - Cilla S
AD  - UO di Fisica Sanitaria, Fondazione di Ricerca e Cura Giovanni Paolo II, (UCSC), 
      Campobasso, Italy.
FAU - Porcelli, A
AU  - Porcelli A
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
FAU - Alberico, L
AU  - Alberico L
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
FAU - Fidanzio, A
AU  - Fidanzio A
AD  - Istituto di Fisica, Universita Cattolica del Sacro Cuore (UCSC), Rome, Italy.
AD  - UOC di Fisica Sanitaria, Fondazione Policlinico Universitario A. Gemelli, Rome, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20180423
PL  - United States
TA  - Med Biol Eng Comput
JT  - Medical & biological engineering & computing
JID - 7704869
SB  - IM
MH  - Anatomic Landmarks
MH  - Automation
MH  - Humans
MH  - *In Vivo Dosimetry
MH  - *Radiotherapy Dosage
MH  - Radiotherapy, Conformal
MH  - Radiotherapy, Intensity-Modulated
MH  - Reproducibility of Results
MH  - *Software
OTO - NOTNLM
OT  - Dosimetry
OT  - Quality controls in radiotherapy
OT  - Radiotherapy in vivo dosimetry
EDAT- 2018/04/24 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/04/24 06:00
PHST- 2016/10/20 00:00 [received]
PHST- 2018/03/26 00:00 [accepted]
PHST- 2018/04/24 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/04/24 06:00 [entrez]
AID - 10.1007/s11517-018-1822-3 [pii]
AID - 10.1007/s11517-018-1822-3 [doi]
PST - ppublish
SO  - Med Biol Eng Comput. 2018 Oct;56(10):1939-1947. doi: 10.1007/s11517-018-1822-3. 
      Epub 2018 Apr 23.