PMID- 29684616
OWN - NLM
STAT- MEDLINE
DCOM- 20180810
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 141
DP  - 2018 Jul
TI  - Serum fibrinogen predicts diabetic ESRD in patients with type 2 diabetes 
      mellitus.
PG  - 1-9
LID - S0168-8227(18)30148-7 [pii]
LID - 10.1016/j.diabres.2018.04.025 [doi]
AB  - AIMS: Although increased serum fibrinogen level was often observed in patients 
      with diabetic nephropathy (DN), its association with DN severity and progression 
      remains unclear. The aim of this study was to investigate the relationship 
      between the serum fibrinogen levels and clinicopathological features and renal 
      prognosis in Chinese patients with type 2 diabetes mellitus (T2DM) and DN. 
      METHODS: A total of 174 patients with T2DM and biopsy-proven DN were enrolled. 
      Patients were stratified by the quartiles of serum fibrinogen levels; Q1: 
      <3.30 g/L; Q2: between 3.30 and 4.00 g/L; Q3: between 4.00 and 4.74 g/L; 
      Q4:>/=4.74 g/L. The renal outcomes were defined by reaching end stage renal disease 
      (ESRD). The influence of serum fibrinogen levels on renal outcomes was evaluated 
      using Cox regression analysis. RESULTS: The factors associated with higher level 
      of fibrinogen (Q3 and Q4) were diabetic retinopathy, low e-GFR, high proteinuria 
      and severe glomerular and tubulointerstitial lesions. Importantly, in adjusted 
      analysis, higher levels of fibrinogen were independently related with a greater 
      risk of reaching ESRD with a hazard ratio (HR) of 1.64 per standard deviation 
      (SD) of the natural log-transformed fibrinogen concentration (95%CI, 1.22-2.20; 
      p = 0.001). In reference to the Q1, the risk of renal failure increased by 
      quartiles of the serum fibrinogen level: the HRs were 7.12 for the Q2 (95%CI, 
      2.29-22.16; p = 0.001), 5.77 for Q3 (95%CI, 1.99-16.75; p = 0.001), and 8.81 for 
      Q4 (95%CI, 2.79-27.80; p < 0.001). CONCLUSIONS: These findings suggested that the 
      elevated serum levels of fibrinogen were associated with diabetic ESRD in 
      patients with T2DM.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Zhang, Junlin
AU  - Zhang J
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Wang, Yiting
AU  - Wang Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Li, Hanyu
AU  - Li H
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Han, Qianqian
AU  - Han Q
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Wu, Yucheng
AU  - Wu Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Wang, Shanshan
AU  - Wang S
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Guo, Ruikun
AU  - Guo R
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Wang, Tingli
AU  - Wang T
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Li, Li
AU  - Li L
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China.
FAU - Liu, Fang
AU  - Liu F
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu 
      610041, China. Electronic address: liufangfh@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180421
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood/pathology
MH  - Diabetic Nephropathies/*blood/diagnosis/pathology
MH  - Disease Progression
MH  - Female
MH  - Fibrinogen/*adverse effects
MH  - Humans
MH  - Kidney/*pathology
MH  - Kidney Failure, Chronic/*blood/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Serum fibrinogen level
OT  - Type 2 diabetes mellitus
OT  - end stage renal disease (ESRD)
EDAT- 2018/04/24 06:00
MHDA- 2018/08/11 06:00
CRDT- 2018/04/24 06:00
PHST- 2018/01/23 00:00 [received]
PHST- 2018/03/19 00:00 [revised]
PHST- 2018/04/12 00:00 [accepted]
PHST- 2018/04/24 06:00 [pubmed]
PHST- 2018/08/11 06:00 [medline]
PHST- 2018/04/24 06:00 [entrez]
AID - S0168-8227(18)30148-7 [pii]
AID - 10.1016/j.diabres.2018.04.025 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Jul;141:1-9. doi: 10.1016/j.diabres.2018.04.025. 
      Epub 2018 Apr 21.