PMID- 29685094 OWN - NLM STAT- MEDLINE DCOM- 20181002 LR - 20181004 IS - 1347-6947 (Electronic) IS - 0916-8451 (Linking) VI - 82 IP - 8 DP - 2018 Aug TI - Effects of alcoholic beverage treatment on spatial learning and fear memory in mice. PG - 1417-1424 LID - 10.1080/09168451.2018.1464898 [doi] AB - Although chronic ethanol treatment is known to impair learning and memory, humans commonly consume a range of alcoholic beverages. However, the specific effects of some alcoholic beverages on behavioral performance are largely unknown. The present study compared the effects of a range of alcoholic beverages (plain ethanol solution, red wine, sake and whiskey; with a matched alcohol concentration of 10%) on learning and memory. 6-week-old C57BL6J mice were orally administered alcohol for 7 weeks. The results revealed that red wine treatment exhibited a trend toward improvement of spatial memory and advanced extinction of fear memory. Additionally, red wine treatment significantly increased mRNA levels of brain-derived neurotrophic factor (BDNF) and N-methyl-D-aspartate (NMDA) receptors in mice hippocampus. These results support previous reports that red wine has beneficial effects. FAU - Hashikawa-Hobara, Narumi AU - Hashikawa-Hobara N AUID- ORCID: 0000-0003-0556-3665 AD - a Department of Life Science , Okayama University of Science , Okayama , Japan. FAU - Mishima, Shuta AU - Mishima S AD - a Department of Life Science , Okayama University of Science , Okayama , Japan. FAU - Nagase, Shotaro AU - Nagase S AD - a Department of Life Science , Okayama University of Science , Okayama , Japan. FAU - Morita, Keishi AU - Morita K AD - a Department of Life Science , Okayama University of Science , Okayama , Japan. FAU - Otsuka, Ami AU - Otsuka A AD - a Department of Life Science , Okayama University of Science , Okayama , Japan. FAU - Hashikawa, Naoya AU - Hashikawa N AD - a Department of Life Science , Okayama University of Science , Okayama , Japan. LA - eng PT - Journal Article DEP - 20180424 PL - England TA - Biosci Biotechnol Biochem JT - Bioscience, biotechnology, and biochemistry JID - 9205717 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (RNA, Messenger) RN - 0 (Receptors, N-Methyl-D-Aspartate) SB - IM MH - Administration, Oral MH - *Alcoholic Beverages MH - Animals MH - Behavior, Animal MH - Brain-Derived Neurotrophic Factor/genetics MH - *Fear MH - Hippocampus/metabolism MH - Male MH - *Memory MH - Mice, Inbred C57BL MH - RNA, Messenger/metabolism MH - Real-Time Polymerase Chain Reaction MH - Receptors, N-Methyl-D-Aspartate/genetics MH - *Spatial Learning OTO - NOTNLM OT - BDNF OT - NMDA receptor OT - Red wine OT - mice EDAT- 2018/04/25 06:00 MHDA- 2018/10/03 06:00 CRDT- 2018/04/25 06:00 PHST- 2018/04/25 06:00 [pubmed] PHST- 2018/10/03 06:00 [medline] PHST- 2018/04/25 06:00 [entrez] AID - 10.1080/09168451.2018.1464898 [doi] PST - ppublish SO - Biosci Biotechnol Biochem. 2018 Aug;82(8):1417-1424. doi: 10.1080/09168451.2018.1464898. Epub 2018 Apr 24.