PMID- 29686173
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20180918
IS  - 0125-9326 (Print)
IS  - 0125-9326 (Linking)
VI  - 50
IP  - 1
DP  - 2018 Jan
TI  - Indonesia Cohort of IO HAT Study to Evaluate Diabetes Management, Control, and 
      Complications in Retrospective and Prospective Periods Among Insulin-Treated 
      Patients with Type 1 and Type 2 Diabetes.
PG  - 26-37
AB  - BACKGROUND: hypoglycemia is a major adverse event of insulin therapy for diabetes 
      mellitus patients. The study was conducted to evaluate the incidence of 
      hypoglycemia among insulin treated patients with type 1 diabetes mellitus (T1DM) 
      or type 2 diabetes mellitus (T2DM) in the Indonesian cohort. METHODS: this 
      Indonesian cohort study consisted of retrospective and prospective evaluation of 
      hypoglycemic episodes, using International Operations Hypoglycemia Assessment 
      Tool (IO HAT) in 374 patients with diabetes (T1DM; n=17 or T2DM; n=357). The 
      patients of >/=18 years of age and treated with insulin for >12 months were 
      selected for this study (ClinicalTrials.gov number: NCT02306681). RESULTS: a 
      total of 374 patients were enrolled in this study and completed SAQ1. All 
      patients with T1DM (17 [100%]), and 347 (97.2%) patients with T2DM completed 
      SAQ2. Almost all the patients in the 4-week prospective period reported at least 
      one hypoglycemic event (T1DM 100%, T2DM 99.4%) and the incidence rate of any 
      hypoglycemia was 67.5 events per patient-year (PPY) and 25.7 events PPY for T1DM 
      and T2DM patients, respectively. Among patients with T1DM and T2DM, 5.9% and 
      36.4%, respectively, did not know what hypoglycemia was at baseline, also high 
      proportion of patients had impaired hypoglycemic awareness in the study (82.4% 
      and 62.7%, respectively). CONCLUSION: overall, high proportion of patients 
      reported hypoglycemic events in the prospective period indicating under reporting 
      during the retrospective period due to recall bias. Therefore, there is a need 
      for patient education program to improve the awareness of hypoglycemia in 
      diabetes patient in Indonesia.
FAU - Rudijanto, Achmad
AU  - Rudijanto A
AD  - Department of Internal Medicine, Faculty of Medicine, Brawijaya University, 
      Malang, Indonesia. achmadrudijanto@yahoo.co.id.
FAU - Saraswati, Made R
AU  - Saraswati MR
FAU - Yunir, Em
AU  - Yunir E
FAU - Kumala, Poppy
AU  - Kumala P
FAU - Puteri, Happy Hs
AU  - Puteri HH
FAU - Mandang, Veny Vv
AU  - Mandang VV
LA  - eng
SI  - ClinicalTrials.gov/NCT02306681
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PL  - Indonesia
TA  - Acta Med Indones
JT  - Acta medica Indonesiana
JID - 7901042
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 1/complications/*drug therapy
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Hypoglycemia/*epidemiology
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Incidence
MH  - Indonesia/epidemiology
MH  - Insulin/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Patient Admission/statistics & numerical data
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - Hypoglycemia
OT  - Indonesia
OT  - International Operations Hypoglycemia Assessment Tool
OT  - insulin-treated patients with diabetes
OT  - observational
EDAT- 2018/04/25 06:00
MHDA- 2018/09/19 06:00
CRDT- 2018/04/25 06:00
PHST- 2018/04/25 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PST - ppublish
SO  - Acta Med Indones. 2018 Jan;50(1):26-37.