PMID- 29686678
OWN - NLM
STAT- MEDLINE
DCOM- 20190606
LR  - 20190606
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Immunoglobulin E-Mediated Autoimmunity.
PG  - 689
LID - 10.3389/fimmu.2018.00689 [doi]
LID - 689
AB  - The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, 
      which may be termed autoallergy, is in its infancy. It is now recognized that 
      systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, 
      both spontaneous and inducible, are most likely to be mediated, at least in part, 
      by IgE autoantibodies. The situation in other conditions, such as autoimmune 
      uveitis, rheumatoid arthritis, hyperthyroid Graves' disease, autoimmune 
      pancreatitis, and even asthma, is far less clear but evidence for autoallergy is 
      accumulating. To be certain of an autoallergic mechanism, it is necessary to 
      identify both IgE autoantibodies and their targets as has been done with the 
      transmembrane protein BP180 and the intracellular protein BP230 in BP and IL-24 
      in chronic spontaneous urticaria. Also, IgE-targeted therapies, such as anti-IgE, 
      must have been shown to be of benefit to patients as has been done with both of 
      these conditions. This comprehensive review of the literature on IgE-mediated 
      autoallergy focuses on three related questions. What do we know about the 
      prevalence of IgE autoantibodies and their targets in different diseases? What do 
      we know about the relevance of IgE autoantibodies in different diseases? What do 
      we know about the cellular and molecular effects of IgE autoantibodies? In 
      addition to providing answers to these questions, based on a broad review of the 
      literature, we outline the current gaps of knowledge in our understanding of IgE 
      autoantibodies and describe approaches to address them.
FAU - Maurer, Marcus
AU  - Maurer M
AD  - Department of Dermatology and Allergy, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Altrichter, Sabine
AU  - Altrichter S
AD  - Department of Dermatology and Allergy, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Schmetzer, Oliver
AU  - Schmetzer O
AD  - Department of Dermatology and Allergy, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Scheffel, Jorg
AU  - Scheffel J
AD  - Department of Dermatology and Allergy, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Church, Martin K
AU  - Church MK
AD  - Department of Dermatology and Allergy, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Metz, Martin
AU  - Metz M
AD  - Department of Dermatology and Allergy, Charite - Universitatsmedizin Berlin, 
      Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180409
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Autoantibodies)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Autoantibodies/immunology
MH  - Autoimmune Diseases/immunology
MH  - *Autoimmunity
MH  - Humans
MH  - Immunoglobulin E/*immunology
PMC - PMC5900004
OTO - NOTNLM
OT  - autoallergy
OT  - bullous pemphigoid
OT  - immunoglobulin E-mechanisms
OT  - immunoglobulin E-mediated autoimmunity
OT  - urticaria
EDAT- 2018/04/25 06:00
MHDA- 2018/04/25 06:01
PMCR- 2018/01/01
CRDT- 2018/04/25 06:00
PHST- 2018/02/02 00:00 [received]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/04/25 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/04/25 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.00689 [doi]
PST - epublish
SO  - Front Immunol. 2018 Apr 9;9:689. doi: 10.3389/fimmu.2018.00689. eCollection 2018.