PMID- 29686948
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240314
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 6
DP  - 2018
TI  - You can't fix what isn't broken: eight weeks of exercise do not substantially 
      change cognitive function and biochemical markers in young and healthy adults.
PG  - e4675
LID - 10.7717/peerj.4675 [doi]
LID - e4675
AB  - OBJECTIVE: The benefits of exercise on brain health is well known in aging and 
      psychiatric populations. However, the relationship between habitual exercise in 
      young and healthy adults remains unclear. This study explored the effects an 
      eight-week exercise prescription on cognitive function, brain-derived 
      neurotrophic factor (BDNF) and cathepsin B (CTHB) in young and healthy adults. 
      METHODS: A total of 22 low-active, young and healthy adults were recruited from a 
      local university. A total of 12 participants performed an eight-week exercise 
      prescription and 12 participants served as controls. Cognitive assessments, 
      cardiorespiratory fitness and plasma BDNF and CTHB concentrations were measured 
      at baseline and eight weeks. RESULTS: Results showed exercise improved 
      cardiorespiratory fitness (p = 0.044, d = 1.48) with no improvements in cognitive 
      function or no changes in plasma BDNF and CTHB concentrations. CONCLUSION: We 
      provide evidence that a short-term course of moderate exercise does not improve 
      cognitive function or change plasma biochemical markers concentrations in young 
      and healthy adults, despite mild improvements in cardiorespiratory fitness. These 
      results suggest that cognitive health may peak during early adulthood leaving 
      little room for improvement throughout this period of the lifespan.
FAU - Gourgouvelis, Joanne
AU  - Gourgouvelis J
AD  - Department of Science, University of Ontario Institute of Technology, Oshawa, ON, 
      Canada.
FAU - Yielder, Paul
AU  - Yielder P
AD  - Department of Health Science, University of Ontario Institute of Technology, 
      Oshawa, ON, Canada.
FAU - Clarke, Sandra T
AU  - Clarke ST
AD  - Department of Science, University of Ontario Institute of Technology, Oshawa, ON, 
      Canada.
FAU - Behbahani, Hushyar
AU  - Behbahani H
AD  - Department of Health Science, University of Ontario Institute of Technology, 
      Oshawa, ON, Canada.
FAU - Murphy, Bernadette
AU  - Murphy B
AUID- ORCID: 0000-0001-9832-5740
AD  - University of Ontario Institute of Technology, Oshawa, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20180419
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC5911384
OTO - NOTNLM
OT  - BDNF
OT  - Cathepsin B
OT  - Cognitive function
OT  - Exercise
COIS- The authors declare that they have no competing interests.
EDAT- 2018/04/25 06:00
MHDA- 2018/04/25 06:01
PMCR- 2018/04/19
CRDT- 2018/04/25 06:00
PHST- 2017/10/25 00:00 [received]
PHST- 2018/04/07 00:00 [accepted]
PHST- 2018/04/25 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/04/25 06:01 [medline]
PHST- 2018/04/19 00:00 [pmc-release]
AID - 4675 [pii]
AID - 10.7717/peerj.4675 [doi]
PST - epublish
SO  - PeerJ. 2018 Apr 19;6:e4675. doi: 10.7717/peerj.4675. eCollection 2018.