PMID- 29687694
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190731
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 32
IP  - 4
DP  - 2018 Jul-Aug
TI  - Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the 
      viewpoint of the patient.
PG  - 983-988
LID - 31 [pii]
AB  - Gastroesophageal reflux disease (GERD) is a very common disease, as about a 
      quarter of the Western population has GERD symptoms at least weekly and GERD is 
      the most frequent reason for outpatient gastroenterology consultation. GERD 
      treatment is based on proton pump inhibitor (PPI) use, but PPI may be ineffective 
      in some patients and potentially unsafe if administered for very long time. A new 
      medical compound (Marial(R)) has been introduced on the Italian market. This 
      product contains magnesium alginate and a phytopolymer: it may be able to repair 
      ulcer/erosion, protect mucosal tissue, and contrast acid contents. The current 
      survey was conducted on a large group of GERD patients visited at 56 Italian 
      gastroenterological offices. Patients were treated with PPI alone, PPI plus 
      add-on, or Marial(R) for 4 weeks: the choice was decided by each gastroenterologist 
      on the basis of the best practice criterion. A reflux symptoms index (RSI) 
      questionnaire was used to weekly assess the clinical features. Marial(R) and PPI 
      plus add-on significantly reduced RSI scores, from the second week. Noteworthy, 
      Marial(R) was more effective than PPI plus add-on. In conclusion, the current 
      survey demonstrated that patients with GERD perceived a significant improvement 
      of GERD symptoms measured by the RSI questionnaire. Marial(R) was as effective as 
      PPI plus add-on.
CI  - Copyright (c) by BIOLIFE, s.a.s. This publication and/or article is for individual 
      use only and may not be further reproduced without written permission from the 
      copyright holder. Unauthorized reproduction may result in financial and other 
      penalties.
FAU - Bianchetti, M
AU  - Bianchetti M
AD  - Gastroenterologia, Humanitas Mater Domini, Castellanza (VA), Italy
FAU - Peralta, S
AU  - Peralta S
AD  - Endoscopia Digestiva, Policlinico P. Giaccone, Universita di Palermo, Palermo, 
      Italy
FAU - Nicita, R
AU  - Nicita R
AD  - Gastroenterologia, ASP 5, Reggio Calabria, Italy
FAU - Aragona, S E
AU  - Aragona SE
AD  - Center of Regenerative Medicine, Humanitas Mater Domini, Castellanza (VA), Italy
FAU - Ciprandi, G
AU  - Ciprandi G
AD  - Center of Regenerative Medicine, Humanitas Mater Domini, Castellanza (VA), Italy
CN  - EMERGE Study Group: A. Arrigoni, D. Artuso, M. Astegiano, C. Azzinnari, E. 
      Battaglia, C. Belcari, E. Bendia, P. Benedicenti, M. Bianchetti, G. Brandimarte, 
      I. Buoncompagni, M. Cabras, S. Camilleri, G. Capece, S. Caronna, C. Cassieri, F. 
      Castaldo, T. Catalano, C. Citarella, F. D'Amore, G. D'Alia, F. D'Arpa, A. 
      Dattola, N. De Bortoli, A. De Medici, S. Di Marzo, R. Di Mitri, A. Di Napoli, V. 
      D'Onofrio, L. Dughera, W. Elisei, G. Errico, L. Familiari, P. Familiari, R. 
      Frasca, A. Frunzio, M. Gatti, S. Genova, S. Grosso, R. Gullotta, D.R. 
      Iannuzziello, G. Indennitate, G. Leonardi, C. Luigiano, B. Macchiarella, T. 
      Maisto, M.G. Mancino, A. Mancino, G. Manes, R. Marin, G.R. Mastinu, A. Moi, L.M. 
      Montalbano, N. Monterosso, A. Morabito Loprete, L. Morlando, R. Nicita, C. 
      Ogliari, N. Paiano Primaldo, G. Paliani, A.P. Palieri, D. Pardocchi, A. Pati, G. 
      Pedretti, S. Peralta, A. Pisani, P. Plomaritis, A.C. Privitera, R. Pumpo, F. 
      Quatraro, D. Raimondo, G. Rivellini, L. Rizzo Giovanni, M. Romano, R. Salerno, E. 
      Savarino, G. Scarpulla, E. Sinagra, M. Soncini, G. Tammaro, C. Trovato, R. 
      Vassallo, M. Vinti, C.M.P. Virgilio.
AD  - Ospedale Policlinico San Martino, Genoa, Italy
LA  - eng
PT  - Letter
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Gastrointestinal Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Gastrointestinal Agents/*therapeutic use
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - gastroesophageal reflux disease
OT  - patients
OT  - RSI
OT  - PPI
OT  - Marial(R)
EDAT- 2018/04/25 06:00
MHDA- 2019/05/07 06:00
CRDT- 2018/04/25 06:00
PHST- 2018/04/25 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
AID - 31 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2018 Jul-Aug;32(4):983-988.