PMID- 29687853
OWN - NLM
STAT- MEDLINE
DCOM- 20191107
LR  - 20210816
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 22
IP  - 7
DP  - 2018 Apr
TI  - LncRNA LINC01116 competes with miR-145 for the regulation of ESR1 expression in 
      breast cancer.
PG  - 1987-1993
LID - 14726 [pii]
LID - 10.26355/eurrev_201804_14726 [doi]
AB  - OBJECTIVE: To investigate the biological role and clinical significance of long 
      non-coding RNAs (lncRNA) LINC01116 in breast cancer. MATERIALS AND METHODS: In 
      the public database Gene Expression Omnibus (GEO), the breast cancer data set 
      GSE54002 was screened for differentially expressed lncRNA LINC01116 in breast 
      cancer tissues and paracancerous tissues. Quantitative Real-time polymerase chain 
      reaction (qRT-PCR) was used to detect the expression of LINC01116 in 64 breast 
      cancer tissues and 30 normal breast tissues. Level of LINC01116 and 
      clinicopathological parameters of breast cancer were statistically analyzed. The 
      effect of LINC01116 in breast cancer cells was investigated after knockdown of 
      LINC01116. Luciferase reporter gene was further used to investigate the mechanism 
      of endogenous RNA (ceRNA). RESULTS: Results of GSE54002 showed that the 
      expression of LINC01116 in breast cancer tissues was significantly increased. In 
      clinical samples, the level of LINC01116 in patients with breast cancer was 
      significantly increased, which was correlated with the overall survival, tumor 
      size and tumor node metastasis (TNM) stage in patients, but not correlated with 
      the age, sex and lymph node metastasis (p>0.05). LINC01116 can act as an 
      endogenous sponge and bind directly to miR-145, resulting in the up-regulation of 
      estrogen receptor 1 (ESR1), a target gene of miR-145. CONCLUSIONS: LncRNA 
      LINC01116 is highly expressed in breast cancer and is a new prognostic biomarker 
      in breast cancer. Our study establishes a new link between LINC01116, miR-145 and 
      ESR1.
FAU - Hu, H-B
AU  - Hu HB
AD  - Department of General Surgery, Shenzhen Guangming New District Central Hospital, 
      Shenzhen, China. Huhaibei2017@126.com.
FAU - Chen, Q
AU  - Chen Q
FAU - Ding, S-Q
AU  - Ding SQ
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (MIRN145 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/genetics/mortality/*pathology
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - MicroRNAs/*physiology
MH  - Middle Aged
MH  - RNA, Long Noncoding/*physiology
EDAT- 2018/04/25 06:00
MHDA- 2019/11/08 06:00
CRDT- 2018/04/25 06:00
PHST- 2018/04/25 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2019/11/08 06:00 [medline]
AID - 14726 [pii]
AID - 10.26355/eurrev_201804_14726 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):1987-1993. doi: 
      10.26355/eurrev_201804_14726.