PMID- 29688525 OWN - NLM STAT- MEDLINE DCOM- 20190524 LR - 20190524 IS - 1096-0929 (Electronic) IS - 1096-0929 (Linking) VI - 164 IP - 1 DP - 2018 Jul 1 TI - Particulate Matter Triggers Depressive-Like Response Associated With Modulation of Inflammatory Cytokine Homeostasis and Brain-Derived Neurotrophic Factor Signaling Pathway in Mice. PG - 278-288 LID - 10.1093/toxsci/kfy086 [doi] AB - Particulate matter (PM) exposure may contribute to depressive-like response in mice. However, few studies have evaluated the adaptive impacts of long-term PM exposure on depressive-like response associated with systemic inflammation and brain-derived neurotrophic factor (BDNF) signaling pathway. We studied the association among depressive-like behaviors, mRNA levels of pro and anti-inflammatory cytokines, and the expression of BDNF signaling pathway in mice by long-term PM exposure. C57BL/6 male mice were exposed to ambient air alongside control mice breathing air filtered through a high-efficiency air PM (HEPA) filter. Depressive-like behaviors were assessed together with proinflammatory, anti-inflammatory cytokine mRNA levels and the modulation of BDNF pathway in hippocampus and olfactory-bulb of mice exposed to PM for 4, 8, and 12 weeks. Exposure to HEPA-filtered air for 4 weeks may exert antidepressant like effects in mice. Proinflammatory cytokines were up-regulated while the expression of BDNF, its high-affinity receptor tropomyosin-related kinase B (TrkB), and the transcription factor (cyclic adenosine monophosphate)-response element-binding protein (CREB) were down-regulated in ambient air mice. However, after 8 weeks, there was no significant difference in the rate of depressive-like behaviors between the 2 groups. After 12 weeks, mice exposed to ambient air again had a higher rate of depressive-like behaviors, significant up-regulation of proinflammatory cytokines, down-regulation of interleukin-10, BDNF, TrkB, and CREB than HEPA mice. Ultrafine PM in brain tissues of mice exposed to ambient air was observed. Our results suggest continuous high-level PM exposure alters the depressive-like response in mice and induces a damage-repair-imbalance reaction. FAU - Liu, Xuemei AU - Liu X AD - State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. AD - School of the Chemical Engineering, Huaiyin Institute of Technology, Huaian 223003, China. FAU - Qian, Xin AU - Qian X AD - State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. AD - Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (CICAEET), Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Xing, Jing AU - Xing J AD - School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China. FAU - Wang, Jinhua AU - Wang J AD - State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. FAU - Sun, Yixuan AU - Sun Y AD - State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. FAU - Wang, Qin'geng AU - Wang Q AD - State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. AD - Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (CICAEET), Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Li, Huiming AU - Li H AD - State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Toxicol Sci JT - Toxicological sciences : an official journal of the Society of Toxicology JID - 9805461 RN - 0 (Air Pollutants) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cytokines) RN - 0 (Particulate Matter) SB - IM MH - Air Pollutants/*toxicity MH - Animals MH - Behavior, Animal/drug effects MH - Brain/*drug effects/immunology/metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Cytokines/*metabolism MH - Depression/*chemically induced/immunology/metabolism MH - Dose-Response Relationship, Drug MH - Homeostasis MH - Inhalation Exposure MH - Male MH - Mice, Inbred C57BL MH - Particle Size MH - Particulate Matter/*toxicity MH - Signal Transduction EDAT- 2018/04/25 06:00 MHDA- 2019/05/28 06:00 CRDT- 2018/04/25 06:00 PHST- 2018/04/25 06:00 [pubmed] PHST- 2019/05/28 06:00 [medline] PHST- 2018/04/25 06:00 [entrez] AID - 4983939 [pii] AID - 10.1093/toxsci/kfy086 [doi] PST - ppublish SO - Toxicol Sci. 2018 Jul 1;164(1):278-288. doi: 10.1093/toxsci/kfy086.