PMID- 29688806
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20221207
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 16
IP  - 5
DP  - 2018 Jun
TI  - Relationships Among C-Reactive Protein, Alanine Aminotransferase, and Metabolic 
      Syndrome in Apparently Healthy Chinese Subjects.
PG  - 232-239
LID - 10.1089/met.2017.0059 [doi]
AB  - AIM: Elevated levels of C-reactive protein (CRP) and alanine aminotransferase 
      (ALT) are tightly associated with metabolic syndrome (MetS). However, it is 
      unclear whether the combination of normal CRP and ALT increases probability of 
      the presence of MetS. MATERIALS AND METHODS: We enrolled 433 Chinese in health 
      screening with both CRP and ALT in normal range. They were divided into four 
      groups: both low (BL, both low baseline CRP and ALT), only high CRP (HCRP), only 
      high ALT (HALT), and both high (BH, both high baseline CRP and ALT) in different 
      genders. The receiver operating characteristic curve was used for comparing the 
      sensitivity and assessing the cutoff point. RESULTS: The BH group had more 
      numbers of MetS components than the BL group. Addition of CRP and ALT did not 
      further increase the accuracy of predicting MetS with a sensitivity of 65.1% and 
      a specificity of 59.1% in men, and a sensitivity of 77.8% and a specificity of 
      60.2% in women. The area under curve for ALT was greater than that for CRP (0.62 
      vs. 0.524 in men; 0.663 vs. 0.598 in women). After adjusting for age, ALT could 
      significantly predict the incidental MetS in both genders; nevertheless, CRP 
      failed to demonstrate prediction. The formula of probability of occurrence of 
      MetS was established on CRP and ALT. CONCLUSIONS: Healthy subjects with high 
      baseline ALT may be at risk of developing MetS, and early recognition and 
      prevention are important for health providers. We concluded that local liver 
      inflammation is significantly associated with the presence of MetS compared with 
      systemic inflammation in health screening subjects.
FAU - Huang, Hsin-Hung
AU  - Huang HH
AD  - 1 Division of Gastroenterology, Department of Internal Medicine, Tri-Service 
      General Hospital, National Defense Medical Center , Taipei, Taiwan, Republic of 
      China .
FAU - Chen, Yen-Lin
AU  - Chen YL
AD  - 2 Department of Pathology, Cardinal Tien Hospital, Medical School, Catholic Fu 
      Jen University , Xindian, Taiwan, Republic of China .
FAU - Chen, Jin-Shuen
AU  - Chen JS
AD  - 3 Division of Nephrology, Department of Internal Medicine, Tri-Service General 
      Hospital, National Defense Medical Center , Taipei, Taiwan, Republic of China .
FAU - Lin, Jiunn-Diann
AU  - Lin JD
AD  - 4 Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      School of Medicine, College of Medicine, Taipei Medical University , Taipei, 
      Taiwan, Republic of China .
AD  - 5 Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Shuang Ho Hospital, Taipei Medical University , Taipei, Taiwan, Republic of China 
      .
FAU - Hsieh, Chang-Hsun
AU  - Hsieh CH
AD  - 6 Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Defense Medical Center , Tri-Service General Hospital, Taipei, Taiwan, 
      Republic of China .
FAU - Pei, Dee
AU  - Pei D
AD  - 7 Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Cardinal Tien Hospital, Medical School, Catholic Fu Jen University , Xindian, 
      Taiwan, Republic of China .
FAU - Wu, Chung-Ze
AU  - Wu CZ
AD  - 4 Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      School of Medicine, College of Medicine, Taipei Medical University , Taipei, 
      Taiwan, Republic of China .
AD  - 5 Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Shuang Ho Hospital, Taipei Medical University , Taipei, Taiwan, Republic of China 
      .
LA  - eng
PT  - Journal Article
DEP - 20180424
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Aging
MH  - Alanine Transaminase/*blood
MH  - Asian People
MH  - C-Reactive Protein/*analysis
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*blood
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Sex Factors
OTO - NOTNLM
OT  - C-reactive protein
OT  - alanine aminotransferase
OT  - metabolic syndrome
EDAT- 2018/04/25 06:00
MHDA- 2019/05/11 06:00
CRDT- 2018/04/25 06:00
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/04/25 06:00 [entrez]
AID - 10.1089/met.2017.0059 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2018 Jun;16(5):232-239. doi: 10.1089/met.2017.0059. 
      Epub 2018 Apr 24.