PMID- 29689690
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 227
DP  - 2018 Feb
TI  - Changes in miRNA-132 and miR-124 levels in non-treated and citalopram-treated 
      patients with depression.
PG  - 745-751
LID - S0165-0327(17)32006-2 [pii]
LID - 10.1016/j.jad.2017.11.090 [doi]
AB  - BACKGROUND: Neurotrophins including brain-derived neurotropic factor (BDNF) are 
      implicated in the pathogenesis of major depressive disorder (MDD). Yet, the roles 
      of brain-specific BDNF-related miRNAs miR-132 and miR-124 are unclear. METHODS: 
      We enrolled 45 treatment-free patients with MDD, 32 citalopram-treated patients 
      with MDD, and 32 healthy control subjects. Participants were assessed with the 
      Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA). In a 
      case-control sub-study, we followed 14 treatment-free patients who were 
      subsequently treated with citalopram for 2 months. Enzyme-linked immunosorbent 
      assay was used to detect plasma BDNF, and real-time polymerase chain reaction was 
      used to quantify relative plasma miR-132 and miR-124 expression. RESULTS: 
      Patients with MDD had significantly higher HAMA and HAMD scores than the control 
      group, with the highest scores in the treatment-free MDD group. Plasma miR-132 in 
      the treatment-free MDD group was 2.4-fold that in the control group and 
      significantly higher than that in the citalopram-treated MDD group. Plasma 
      miR-124 in the treatment-free MDD and citalopram-treated MDD groups was 1.8-fold 
      and 4-fold that in the control group, respectively. Compared to the control 
      group, plasma BDNF levels were increased in both MDD groups, but not 
      significantly different between them. There was a positive correlation between 
      miR-132 and HAMD and HAMA scores, whereas no significant correlations were 
      identified for plasma miR-124 or BDNF. LIMITATIONS: The range of 
      neurotrophin-related MiRNAs and the number of follow-up cases were limited. 
      CONCLUSIONS: BDNF and miR-124 in plasma increase with depression and 
      antidepressants. Plasma MiR-132 might be an indication for depression status.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Fang, Yuan
AU  - Fang Y
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      600 South Wan Ping Road, Shanghai 200030, China.
FAU - Qiu, Qi
AU  - Qiu Q
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      600 South Wan Ping Road, Shanghai 200030, China.
FAU - Zhang, Shengyu
AU  - Zhang S
AD  - Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, 
      Institute of Forensic Science, Ministry of Justice, No. 1347, Guangfu West Road, 
      Putuo District, Shanghai 200063, China.
FAU - Sun, Lin
AU  - Sun L
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      600 South Wan Ping Road, Shanghai 200030, China.
FAU - Li, Guanjun
AU  - Li G
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      600 South Wan Ping Road, Shanghai 200030, China.
FAU - Xiao, Shifu
AU  - Xiao S
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      600 South Wan Ping Road, Shanghai 200030, China.
FAU - Li, Xia
AU  - Li X
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      600 South Wan Ping Road, Shanghai 200030, China. Electronic address: 
      ja_1023@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171121
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MIRN124 microRNA, human)
RN  - 0 (MIRN132 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/blood/drug therapy/psychology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Case-Control Studies
MH  - Citalopram/*therapeutic use
MH  - Correlation of Data
MH  - Depressive Disorder, Major/blood/*drug therapy/psychology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood
MH  - Middle Aged
MH  - Primary Health Care
MH  - Psychiatric Status Rating Scales
MH  - Real-Time Polymerase Chain Reaction
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - MiR-124
OT  - MiR-132
OT  - Neurotrophin
EDAT- 2018/04/25 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/04/26 06:00
PHST- 2017/09/27 00:00 [received]
PHST- 2017/11/14 00:00 [revised]
PHST- 2017/11/17 00:00 [accepted]
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
AID - S0165-0327(17)32006-2 [pii]
AID - 10.1016/j.jad.2017.11.090 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Feb;227:745-751. doi: 10.1016/j.jad.2017.11.090. Epub 2017 
      Nov 21.