PMID- 29690626
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20181114
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 4
DP  - 2018 Apr 23
TI  - Effects of Chlorogenic Acid-Enriched and Hydroxyhydroquinone-Reduced Coffee on 
      Postprandial Fat Oxidation and Antioxidative Capacity in Healthy Men: A 
      Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
LID - 10.3390/nu10040525 [doi]
LID - 525
AB  - Chlorogenic acids (CGAs) reduce blood pressure and body fat, and enhance fat 
      metabolism. In roasted coffee, CGAs exist together with the oxidant component 
      hydroxyhydroquinone (HHQ). HHQ counteracts the antihypertensive effects of CGA, 
      but its effects on CGA-induced fat oxidation (FOX) are unknown. Here we assessed 
      the effects of CGA-enriched and HHQ-reduced coffee on FOX. Fifteen healthy male 
      volunteers (age: 38 ± 8 years (mean ± SD); BMI: 22.4 ± 1.5 
      kg/m(2)) participated in this crossover study. Subjects consumed the test beverage 
      (coffee) containing the same amount of CGA with HHQ (CGA-HHQ(+)) or without HHQ 
      (CGA-HHQ(−)) for four weeks. Postprandial FOX and the ratio of the 
      biological antioxidant potential (BAP) to the derivatives of reactive oxygen 
      metabolites (d-ROMs) as an indicator of oxidative stress were assessed. After the 
      four-week intervention, postprandial FOX and the postprandial BAP/d-ROMs ratio 
      were significantly higher in the CGA-HHQ(−) group compared with the 
      CGA-HHQ(+) group (4 ± 23 mg/min, group effect: p = 0.040; 0.27 ± 
      0.74, group effect: p = 0.007, respectively). In conclusion, reducing the amount 
      of HHQ facilitated the postprandial FOX effects of CGA in coffee. Our findings 
      also suggest that the mechanism underlying the inhibition of FOX by HHQ is 
      related to postprandial oxidative stress.
FAU - Katada, Shun
AU  - Katada S
AD  - Biological Science Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida, 
      Tokyo 131-8501, Japan. katada.shun@kao.com.
FAU - Watanabe, Takuya
AU  - Watanabe T
AD  - Biological Science Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida, 
      Tokyo 131-8501, Japan. watanabe.takuya@kao.com.
FAU - Mizuno, Tomohito
AU  - Mizuno T
AD  - Biological Science Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida, 
      Tokyo 131-8501, Japan. mizuno.tomohito@kao.com.
FAU - Kobayashi, Shinichi
AU  - Kobayashi S
AD  - Health Care Food Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida, 
      Tokyo 131-8501, Japan. kobayashi.shinichi@kao.com.
FAU - Takeshita, Masao
AU  - Takeshita M
AD  - Health Care Food Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida, 
      Tokyo 131-8501, Japan. takeshita.masao@kao.com.
FAU - Osaki, Noriko
AU  - Osaki N
AD  - Biological Science Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida, 
      Tokyo 131-8501, Japan. osaki.noriko@kao.com.
FAU - Kobayashi, Shigeru
AU  - Kobayashi S
AD  - Department of Surgery, Tokyo Rinkai Hospital, 1-4-2 Rinkai-cho, Edogawa, Tokyo 
      134-0086, Japan. kobayashi.shigeru1@kao.com.
FAU - Katsuragi, Yoshihisa
AU  - Katsuragi Y
AD  - Health Care Food Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida, 
      Tokyo 131-8501, Japan. katsuragi.yoshihisa@kao.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180423
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antioxidants)
RN  - 0 (Coffee)
RN  - 0 (Hydroquinones)
RN  - 0 (Reactive Oxygen Species)
RN  - 173O8B04RD (hydroxyhydroquinone)
RN  - 318ADP12RI (Chlorogenic Acid)
SB  - IM
MH  - Adult
MH  - Antioxidants/*administration & dosage/adverse effects/analysis
MH  - Chlorogenic Acid/*administration & dosage/adverse effects/analysis
MH  - Coffee/adverse effects/*chemistry
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Healthy Volunteers
MH  - Humans
MH  - Hydroquinones/*analysis
MH  - Lipid Metabolism/*drug effects
MH  - Male
MH  - *Men's Health
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Oxidative Stress/drug effects
MH  - *Postprandial Period
MH  - Reactive Oxygen Species/blood
MH  - Tokyo
PMC - PMC5946310
OTO - NOTNLM
OT  - chlorogenic acids
OT  - fat oxidation
OT  - hydroxyhydroquinone
OT  - oxidative stress
COIS- The authors declare no conflicts of interest. This work was financed by Kao 
      Corporation and no external funding was received.
EDAT- 2018/04/25 06:00
MHDA- 2018/09/25 06:00
PMCR- 2018/04/01
CRDT- 2018/04/26 06:00
PHST- 2018/03/27 00:00 [received]
PHST- 2018/04/12 00:00 [revised]
PHST- 2018/04/18 00:00 [accepted]
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - nu10040525 [pii]
AID - nutrients-10-00525 [pii]
AID - 10.3390/nu10040525 [doi]
PST - epublish
SO  - Nutrients. 2018 Apr 23;10(4):525. doi: 10.3390/nu10040525.