PMID- 29690664
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20181202
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 4
DP  - 2018 Apr 8
TI  - [Clinicopathologic features of gastric plexiform fibromyxoma].
PG  - 258-262
LID - 10.3760/cma.j.issn.0529-5807.2018.04.006 [doi]
AB  - Objective: To analyse the clinicopathologic features of gastric plexiform 
      fibromyxoma (PF) including diagnosis, differential diagnosis, 
      immunohistochemistry and molecular pathology. Methods: Eight cases of PF were 
      collected from June 2006 to June 2017 at the Second Affiliated Hospital of 
      Zhengzhou University and the First Affiliated Hospital of Zhengzhou University. 
      The clinicopathologic findings of eight cases of PF were retrospectively 
      analyzed, and immunohistochemistry (EnVision method) and molecular detection of 
      glioma-associated oncogene homologue 1 (GLI1) gene translocation were performed. 
      All cases were histologically reviewed with immunohistochemical staining for 
      smooth muscle actin (SMA), CD10, CD117, DOG1, CD34, ER, PR, ALK and S-100. 
      Fluorescence in situ hybridization (FISH) was used to detect the GLI1 gene 
      translocation, and mutation of CKIT exons 9, 11, 13 and 17; and PDGFRA exons 12, 
      14 and 18 were identified by Sanger sequencing in four cases. Relevant literature 
      was reviewed. Results: The study included four men and four women, age ranged 
      from 26 to 72 years (mean 51 years). Histologically, the tumors were rich in 
      small thin-walled blood vessels and myxoid matrix, and exhibited multiple nodular 
      growth pattern in the gastric wall. The tumor cells were bland, spindled or oval. 
      Immunohistochemically, all cases strongly expressed vimentin and SMA, and some 
      expressed CD10 (4/8), desmin (3/8), H-caldesmon (5/8) and PR (5/8), but were 
      negative for CD34, S-100, ER, ALK, CD117 and DOG1. The GLI1 gene translocation 
      detection was performed in eight cases by FISH with three positive cases and five 
      negative cases. Mutation analyses for exons 9, 11, 13, and 17 of CKIT genes and 
      exons 12, 14, and 18 of the PDGFRA genes were performed and the tumors all of 
      four tested cases were wild-type. Seven patients were followed up (ranged from 24 
      to 95 months, mean 50 months) after diagnosis and none of the patients had 
      recurrence or metastasis. Conclusions: PF is a rare novel mesenchymal tumor of 
      the stomach. Its distinct clinicopathologic features and immunohistochemical 
      positivity for SMA, CD10 and PR can help differentiating this entity from other 
      gastrointestinal mesenchymal tumors. FISH detection of GLI1 gene translocation 
      offers an additional molecular diagnostic marker for the diagnosis.
FAU - Hu, G M
AU  - Hu GM
AD  - Department of Pathology, the Second Affiliated Hospital of Zhengzhou University, 
      Zhengzhou 450014, China.
FAU - Chen, H P
AU  - Chen HP
AD  - Department of Pathology, the Maternal and Child Health Hospital of Zhengzhou, 
      Zhengzhou 450012, China.
FAU - Liu, Q Y
AU  - Liu QY
FAU - Shi, X C
AU  - Shi XC
FAU - Wu, H F
AU  - Wu HF
FAU - Feng, Y K
AU  - Feng YK
FAU - Ren, J L
AU  - Ren JL
FAU - Wang, C F
AU  - Wang CF
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (Desmin)
RN  - 0 (GLI1 protein, human)
RN  - 0 (Vimentin)
RN  - 0 (Zinc Finger Protein GLI1)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
RN  - EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calmodulin-Binding Proteins/metabolism
MH  - DNA Mutational Analysis
MH  - Desmin/metabolism
MH  - Diagnosis, Differential
MH  - Exons
MH  - Female
MH  - Fibroma/genetics/metabolism/*pathology
MH  - Gastrointestinal Neoplasms/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Neoplasm Recurrence, Local
MH  - Proto-Oncogene Proteins c-kit/genetics
MH  - Receptor, Platelet-Derived Growth Factor alpha/genetics
MH  - Retrospective Studies
MH  - Stomach Neoplasms/metabolism/*pathology
MH  - Translocation, Genetic
MH  - Vimentin/metabolism
MH  - Zinc Finger Protein GLI1/genetics
OTO - NOTNLM
OT  - Diagnosis, differential
OT  - Immunohistochemistry
OT  - Stomach neoplasms
OT  - Translocation, genetic
EDAT- 2018/04/25 06:00
MHDA- 2018/05/01 06:00
CRDT- 2018/04/26 06:00
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2018.04.006 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Apr 8;47(4):258-262. doi: 
      10.3760/cma.j.issn.0529-5807.2018.04.006.