PMID- 29690665 OWN - NLM STAT- MEDLINE DCOM- 20180430 LR - 20181202 IS - 0529-5807 (Print) IS - 0529-5807 (Linking) VI - 47 IP - 4 DP - 2018 Apr 8 TI - [Spindle cell lipoma and pleomorphic lipoma: a clinicopathologic analysis of 65 cases]. PG - 263-268 LID - 10.3760/cma.j.issn.0529-5807.2018.04.007 [doi] AB - Objective: To investigate the clinical and pathological features of spindle cell lipoma (SCL) and pleomorphic lipoma (PL) with emphasis on differential diagnosis. Methods: Sixty-five cases of SCL/PL from the archive of Department of Pathology, Fudan University Shanghai Cancer Center, from August of 2006 to June of 2017, were included in the study. Immunohistochemistry by EnVision method, MDM2 gene amplifycation and DDIT3 gene translocation by fluorescence in situ hybridization(FISH) were detected and the literature was reviewed. Results: There were 53 males and 12 females with age ranging from 26 to 82 years (mean, 57 years; median, 59 years). The majority of the lesions occurred in the neck/posterior neck/nuchal region, upper back and shoulder. A small percentage of lesions developed in the extremities, face and trunk, and rarely in the epiglottis, mediastinum, labium majus and perineum. Clinically, the tumor usually manifested as a slowly growing mass or nodule. It was often encapsulated, ranging from 1 to 13 cm (mean, 4.1 cm; median, 3.5 cm) in size. Microscopically, SCL was composed of mature adipose tissue, bland spindle cells and bright eosinophilic "ropey" collagen fibers that varied in proportion. Of 45 SCL, 28 cases (62.2%) were classical, 6 cases (13.3%) were myxoid, 5 cases (11.1%) were fat-poor, 3 cases (6.7%) were fat-free, and 3 cases (6.5%) were pseudoangiomatoid. PL showed similar features as SCL, but was characterized by the presence of scattered floret giant cells. Of 20 PL, 11 cases (55.0%) were classical, 6 cases (30.0%) were mixed SCL/PL, 3 cases (15.0%) were fat-free. Both SCL and PL contained scattered mast cells in the stroma. By immunohistochemistry, the spindle cells in SCL and the floret giant cells in PL showed strong positivity for CD34 (52/52, 100.0%), bcl-2 (24/26, 92.3%) and CD99 (6/6), whereas they were negative for S-100 protein and STAT6. FISH analysis of MDM2 (17 cases) and DDIT3 (4 cases) was negative in all cases. Follow-up information was available in 32 patients (3 to 96 months), with local recurrence in only one patient. Conclusions: SCL and PL belong to the same entity but may exhibit morphological disparities. Of note, the fat-poor and fat-free variants are easily mistaken for other mesenchymal tumors. Attention should be paid in their differential diagnosis. FAU - Tang, L H AU - Tang LH AD - Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. FAU - Lao, Q Y AU - Lao QY FAU - Yu, L AU - Yu L FAU - Wang, J AU - Wang J LA - chi PT - Journal Article PL - China TA - Zhonghua Bing Li Xue Za Zhi JT - Zhonghua bing li xue za zhi = Chinese journal of pathology JID - 0005331 RN - 0 (12E7 Antigen) RN - 0 (Antigens, CD34) RN - 0 (CD99 protein, human) RN - 0 (DDIT3 protein, human) RN - 0 (S100 Proteins) RN - 0 (STAT6 Transcription Factor) RN - 0 (STAT6 protein, human) RN - 147336-12-7 (Transcription Factor CHOP) RN - EC 2.3.2.27 (MDM2 protein, human) RN - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2) SB - IM MH - 12E7 Antigen/metabolism MH - Adult MH - Aged MH - Aged, 80 and over MH - Antigens, CD34/metabolism MH - China MH - Diagnosis, Differential MH - Female MH - Giant Cells/pathology MH - Humans MH - Immunohistochemistry MH - In Situ Hybridization, Fluorescence MH - Lipoma/genetics/*pathology MH - Male MH - Middle Aged MH - Proto-Oncogene Proteins c-mdm2/genetics MH - S100 Proteins/metabolism MH - STAT6 Transcription Factor/metabolism MH - Transcription Factor CHOP/genetics OTO - NOTNLM OT - Diagnosis, differential OT - Immunohistochemistry OT - In situ hybridization, fluorescence OT - Lipoma EDAT- 2018/04/25 06:00 MHDA- 2018/05/01 06:00 CRDT- 2018/04/26 06:00 PHST- 2018/04/26 06:00 [entrez] PHST- 2018/04/25 06:00 [pubmed] PHST- 2018/05/01 06:00 [medline] AID - 10.3760/cma.j.issn.0529-5807.2018.04.007 [doi] PST - ppublish SO - Zhonghua Bing Li Xue Za Zhi. 2018 Apr 8;47(4):263-268. doi: 10.3760/cma.j.issn.0529-5807.2018.04.007.