PMID- 29691823
OWN - NLM
STAT- MEDLINE
DCOM- 20180814
LR  - 20180814
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1058
DP  - 2018
TI  - Layered Scaffolds for Osteochondral Tissue Engineering.
PG  - 193-218
LID - 10.1007/978-3-319-76711-6_9 [doi]
AB  - Despite huge efforts, tissue engineers and orthopedic surgeons still face a great 
      challenge to functionally repair osteochondral (OC) defects. Nevertheless, over 
      the past decade great progress has been made to find suitables strategies towards 
      OC regeneration. In the clinics, some osteochondral tissue engineering (OCTE) 
      strategies have already been applied although with some incongruous outcomes as 
      OC tissue is complex in its architecture and function. In this chapter, we have 
      summarized current OCTE strategies that are focused on hierarchical scaffold 
      design, mainly layered scaffolds. Most suitable candidates towards functional 
      regeneration of OC tissues are envisaged from monophasic to layered scaffolds. 
      Herein is documented a variety of strategies with their intrinsic properties for 
      further application as bare scaffolds or in combination with biologics. Both in 
      vitro and in vivo approaches have been thoroughly studied aiming at functional OC 
      regeneration. The most noteworthy studies in OC regeneration developed within the 
      past 5 years are herein documented as well as some current clinical trials.
FAU - Pereira, Diana Ribeiro
AU  - Pereira DR
AD  - 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of 
      Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 
      and Regenerative Medicine, Barco, Portugal.
AD  - ICVS/3B's - PT Government Associate Laboratory, Barco, Guimaraes, Portugal.
FAU - Reis, Rui L
AU  - Reis RL
AD  - 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of 
      Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 
      and Regenerative Medicine, Barco, Portugal.
AD  - ICVS/3B's - PT Government Associate Laboratory, Barco, Guimaraes, Portugal.
AD  - The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at 
      University of Minho, Barco, Guimaraes, Portugal.
FAU - Oliveira, J Miguel
AU  - Oliveira JM
AD  - 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of 
      Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 
      and Regenerative Medicine, Barco, Portugal. miguel.oliveira@dep.uminho.pt.
AD  - ICVS/3B's - PT Government Associate Laboratory, Barco, Guimaraes, Portugal. 
      miguel.oliveira@dep.uminho.pt.
AD  - The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at 
      University of Minho, Barco, Guimaraes, Portugal. miguel.oliveira@dep.uminho.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Animals
MH  - *Bone and Bones
MH  - *Cartilage
MH  - Humans
MH  - Tissue Engineering/*methods
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - Functional OC regeneration
OT  - Hierarchical scaffolds
OT  - Multilayered scaffolds
OT  - Osteochondral defects
OT  - Tissue integration
EDAT- 2018/04/25 06:00
MHDA- 2018/08/15 06:00
CRDT- 2018/04/26 06:00
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/25 06:00 [pubmed]
PHST- 2018/08/15 06:00 [medline]
AID - 10.1007/978-3-319-76711-6_9 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1058:193-218. doi: 10.1007/978-3-319-76711-6_9.