PMID- 2969196
OWN - NLM
STAT- MEDLINE
DCOM- 19880812
LR  - 20220409
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 255
IP  - 1 Pt 2
DP  - 1988 Jul
TI  - Vagal C-fiber blockade abolishes sympathetic inhibition by atrial natriuretic 
      factor.
PG  - R6-13
AB  - Administration of atrial natriuretic factor (ANF) to anesthetized rats decreases 
      renal nerve activity (RNA), an effect prevented by vagotomy but not by atropine. 
      We sought to determine whether afferent vagal C-fibers mediate the inhibition of 
      sympathetic outflow. ANF (2.5 micrograms/kg iv) decreased mean arterial pressure 
      (MAP) by 25 +/- 2 mmHg, RNA by 11 +/- 5%, and least splanchnic nerve activity 
      (LSNA) by 10 +/- 4% in anesthetized rats with arterial baroreceptors intact, and 
      by 40 +/- 3 mmHg, 28 +/- 7%, and 23 +/- 4%, respectively, in 
      sinoaortic-denervated rats. Inhibition of RNA and LSNA by ANF was reduced 
      slightly by cooling the vagi to 6 or 7 degrees C, a temperature at which 
      conduction in A-fibers was blocked and that in C-fibers attenuated; inhibition 
      was abolished when C-fibers were blocked by cooling to 0 degrees C. We conclude 
      that the inhibition of RNA and LSNA by ANF was mediated by afferent vagal 
      C-fibers. We also obtained evidence that the aortic nerves contribute to 
      ANF-induced inhibition of RNA. Our results support the notion that ANF evokes a 
      generalized decrease in sympathetic tone that contributes to the hypotension, 
      cardiac inhibition, and natriuresis accompanying systemic administration of the 
      peptide.
FAU - Schultz, H D
AU  - Schultz HD
AD  - Department of Medicine, University of California, San Francisco 94143-0130.
FAU - Gardner, D G
AU  - Gardner DG
FAU - Deschepper, C F
AU  - Deschepper CF
FAU - Coleridge, H M
AU  - Coleridge HM
FAU - Coleridge, J C
AU  - Coleridge JC
LA  - eng
GR  - HL-25847/HL/NHLBI NIH HHS/United States
GR  - HL-33797/HL/NHLBI NIH HHS/United States
GR  - HL-35753/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 169D1260KM (Nitroprusside)
RN  - 7C0697DR9I (Atropine)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Animals
MH  - Atrial Natriuretic Factor/*pharmacology
MH  - Atropine/pharmacology
MH  - Blood Pressure
MH  - Denervation
MH  - Female
MH  - Heart Rate
MH  - Kidney/innervation
MH  - *Nerve Block
MH  - Nerve Fibers/*drug effects
MH  - Nitroprusside/pharmacology
MH  - Pressoreceptors/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Splanchnic Nerves/drug effects
MH  - Sympathetic Nervous System/*drug effects
MH  - Vagotomy
MH  - Vagus Nerve/*drug effects
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
AID - 10.1152/ajpregu.1988.255.1.R6 [doi]
PST - ppublish
SO  - Am J Physiol. 1988 Jul;255(1 Pt 2):R6-13. doi: 10.1152/ajpregu.1988.255.1.R6.