PMID- 29693298
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20190909
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 23
IP  - 11
DP  - 2018 Nov
TI  - Prognostic factors and disease behaviour of pathologically proven fibrotic 
      non-specific interstitial pneumonia.
PG  - 1032-1040
LID - 10.1111/resp.13313 [doi]
AB  - BACKGROUND AND OBJECTIVE: Non-specific interstitial pneumonia (NSIP) has 
      heterogeneous characteristics in terms of background, disease behaviour and 
      prognosis. This study of fibrotic NSIP (f-NSIP) aimed to elucidate prognosis and 
      disease behaviour from the viewpoint of clinical background and determine whether 
      long-term change of pulmonary function could provide useful prognostic 
      information. METHODS: We analysed the medical records of 157 consecutive patients 
      diagnosed with f-NSIP by surgical lung biopsy. Disease behaviour was categorized 
      into two groups depending on long-term change of pulmonary function: progressive 
      type (relative >/=5%/year decline in the slope of forced vital capacity and/or 
      relative >/=7.5%/year decline in the slope of %diffusing capacity of lung carbon 
      monoxide) or stable type. Predictors of disease behaviour and prognosis were 
      determined using logistic and Cox regression models. RESULTS: Our f-NSIP cohort 
      included interstitial pneumonia with autoimmune features (IPAF) (36.9%), 
      idiopathic (non-IPAF) (22.3%) and connective tissue disease-associated 
      interstitial lung disease (40.8%). Multivariate analysis showed that idiopathic 
      (non-IPAF) f-NSIP and progressive type disease were negative prognostic factors 
      of mortality. Poor treatment response at 1 year was an independent predictor of 
      progressive type disease, but was not related to survival. In terms of disease 
      behaviour based on pulmonary function change, some patients with IPAF f-NSIP 
      showed a progressive course. CONCLUSION: Although an IPAF diagnosis was useful 
      for identifying good prognosis in idiopathic f-NSIP, some idiopathic f-NSIP 
      patients with or without IPAF showed progressive disease despite therapy. The 
      definition of progressive type disease may be useful in clinical decision-making 
      when determining therapy for f-NSIP.
CI  - (c) 2018 Asian Pacific Society of Respirology.
FAU - Yamakawa, Hideaki
AU  - Yamakawa H
AUID- ORCID: 0000-0003-2480-6087
AD  - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory 
      Center, Yokohama, Japan.
AD  - Department of Respiratory Medicine, Tokyo Jikei University Hospital, Tokyo, 
      Japan.
FAU - Kitamura, Hideya
AU  - Kitamura H
AD  - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory 
      Center, Yokohama, Japan.
AD  - Department of Respiratory Medicine, Tokyo Jikei University Hospital, Tokyo, 
      Japan.
FAU - Takemura, Tamiko
AU  - Takemura T
AD  - Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan.
FAU - Ikeda, Satoshi
AU  - Ikeda S
AUID- ORCID: 0000-0001-5203-7911
AD  - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory 
      Center, Yokohama, Japan.
FAU - Sekine, Akimasa
AU  - Sekine A
AD  - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory 
      Center, Yokohama, Japan.
FAU - Baba, Tomohisa
AU  - Baba T
AD  - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory 
      Center, Yokohama, Japan.
FAU - Iwasawa, Tae
AU  - Iwasawa T
AD  - Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, 
      Yokohama, Japan.
FAU - Hagiwara, Eri
AU  - Hagiwara E
AUID- ORCID: 0000-0003-0079-7462
AD  - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory 
      Center, Yokohama, Japan.
FAU - Sato, Shinji
AU  - Sato S
AD  - Department of Rheumatology, Tokai University Hospital, Isehara, Japan.
FAU - Ogura, Takashi
AU  - Ogura T
AD  - Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory 
      Center, Yokohama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180424
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
SB  - IM
MH  - Aged
MH  - Autoimmunity
MH  - Biopsy/*methods
MH  - Cohort Studies
MH  - Connective Tissue Diseases/diagnosis/pathology
MH  - Female
MH  - Humans
MH  - Lung/pathology/physiopathology
MH  - *Lung Diseases, Interstitial/diagnosis/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - *Pulmonary Fibrosis/diagnosis/pathology
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/methods
OTO - NOTNLM
OT  - connective tissue disease
OT  - disease behaviour
OT  - interstitial pneumonia with autoimmune features
OT  - non-specific interstitial pneumonia
OT  - prognosis
EDAT- 2018/04/26 06:00
MHDA- 2019/09/10 06:00
CRDT- 2018/04/26 06:00
PHST- 2017/10/03 00:00 [received]
PHST- 2018/02/28 00:00 [revised]
PHST- 2018/03/28 00:00 [accepted]
PHST- 2018/04/26 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2018/04/26 06:00 [entrez]
AID - 10.1111/resp.13313 [doi]
PST - ppublish
SO  - Respirology. 2018 Nov;23(11):1032-1040. doi: 10.1111/resp.13313. Epub 2018 Apr 
      24.