PMID- 29694278
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20240312
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 120
IP  - 2
DP  - 2018 Aug 1
TI  - Signals driving the adaptation of saccades that require spatial updating.
PG  - 525-538
LID - 10.1152/jn.00075.2018 [doi]
AB  - Saccades adapt to persistent natural or artificially imposed dysmetrias. The 
      characteristics and circuitry of saccade adaptation have been revealed using a 
      visually guided task (VGT) where the vectors of the target step and the intended 
      saccade command are the same. However, in real life, another saccade occasionally 
      intervenes before the saccade to the target occurs. This necessitates an updating 
      of the intended saccade to account for the intervening saccadic displacement, 
      which dissociates the visual target signal and the intended saccade command. We 
      determined whether the adaptation process is similar for VGT and updated saccades 
      by studying the transfer of adaptation between them. The ultimate visual target 
      was dissociated from the intended saccade command with double-step saccade tasks 
      (DSTs) in which two targets are flashed sequentially at different locations while 
      the monkey maintains fixation. The resulting saccades toward the first and second 
      targets occur in the dark. The transfer of visually guided saccade adaptation to 
      the second saccades of a DST and vice versa depended on the eccentricity of the 
      second visual target, and not the second saccade command. If a target with the 
      same eccentricity as the adapted target appears briefly during the intersaccadic 
      interval of a DST, more adaptation transfers. Because a brief appearance of the 
      visual target either before the first saccade or during the intersaccadic 
      interval influences how much adaptation transfer the second saccade will express, 
      the processing of adaptation and DST updating may overlap. NEW & NOTEWORTHY 
      Adaptation and the spatial updating of saccades are thought to be independent 
      processes. When we dissociate the visual target and the intended saccade command, 
      the transfer of visually guided saccade adaptation to the saccades of the 
      double-step saccade tasks (DST) and vice versa is driven by a visual not motor 
      error. The visual target has an effect until the second saccade of a DST occurs. 
      Therefore, the processing of adaptation and the spatial updating of saccades may 
      overlap.
FAU - Soetedjo, Robijanto
AU  - Soetedjo R
AD  - Department of Physiology and Biophysics, University of Washington , Seattle, 
      Washington.
AD  - Washington National Primate Research Center, University of Washington , Seattle, 
      Washington.
LA  - eng
GR  - P51 OD010425/OD/NIH HHS/United States
GR  - R01 EY019258/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180425
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
MH  - *Adaptation, Physiological
MH  - Animals
MH  - Eye Movement Measurements
MH  - Fixation, Ocular
MH  - Macaca mulatta
MH  - Photic Stimulation
MH  - Psychomotor Performance
MH  - *Saccades
MH  - *Spatial Processing
PMC - PMC6139442
OTO - NOTNLM
OT  - adaptation
OT  - movement spatial updating
OT  - saccade
OT  - transfer
EDAT- 2018/04/26 06:00
MHDA- 2019/07/30 06:00
PMCR- 2019/08/01
CRDT- 2018/04/26 06:00
PHST- 2018/04/26 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2018/04/26 06:00 [entrez]
PHST- 2019/08/01 00:00 [pmc-release]
AID - JN-00075-2018 [pii]
AID - 10.1152/jn.00075.2018 [doi]
PST - ppublish
SO  - J Neurophysiol. 2018 Aug 1;120(2):525-538. doi: 10.1152/jn.00075.2018. Epub 2018 
      Apr 25.