PMID- 29694639
OWN - NLM
STAT- MEDLINE
DCOM- 20180525
LR  - 20230422
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 62
IP  - 1
DP  - 2018 Feb
TI  - Assessing endocrine and immune parameters in human immunodeficiency 
      virus-infected patients before and after the immune reconstitution inflammatory 
      syndrome.
PG  - 64-71
LID - S2359-39972018000100064 [pii]
LID - 10.20945/2359-3997000000010 [doi]
AB  - Objective The present study compares immune and endocrine parameters between 
      HIV-infected patients who underwent the Immune Reconstitution Inflammatory 
      Syndrome (IRIS-P) during antiretroviral therapy (ART) and HIV-patients who did 
      not undergo the syndrome (non-IRIS-P). Materials and methods Blood samples were 
      obtained from 31 HIV-infected patients (15 IRIS-P and 16 non-IRIS-P) before ART 
      (BT) and 48 +/- 2 weeks after treatment initiation (AT). Plasma Interleukin-6 
      (IL-6) and Interleukin-18 (IL-18) were determined by ELISA. Cortisol, 
      dehydroepiandrosterone sulfate (DHEA-S) and thyroxin concentrations were measured 
      using chemiluminescence immune methods. Results Concentrations of IL-6 (7.9 +/- 1.9 
      pg/mL) and IL-18 (951.5 +/- 233.0 pg/mL) were significantly higher (p < 0.05) in 
      IRIS-P than in non-IRIS-P (3.9 +/- 1.0 pg/mL and 461.0 +/- 84.4 pg/mL, respectively) 
      BT. Mean T4 plasma level significantly decreased in both groups of patients after 
      treatment (p < 0.05). In both groups cortisol levels were similar before and 
      after ART (p > 0.05). Levels of DHEA-S in IRIS-P decreased AT (1080.5 +/- 124.2 vs. 
      782.5 +/- 123.8 ng/mL, p < 0.05) and they were significantly lower than in 
      non-IRIS-P (782.5 +/- 123.8 vs. 1203.7 +/- 144.0 ng/mL, p < 0.05). IRIS-P showed 
      higher values of IL-6 and IL-18 BT and lower levels of DHEA-S AT than in 
      non-IRIS-P. Conclusion These parameters could contribute to differentiate IRIS-P 
      from non-IRIS-P. The significant decrease in DHEA-S levels in IRIS-P after ART 
      might suggest a different adrenal response in these patients, which may reflect 
      the severity of the disease.
FAU - Rateni, Liliana
AU  - Rateni L
AD  - Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Santa Fe, 
      Argentina.
FAU - Lupo, Sergio
AU  - Lupo S
AD  - Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Santa Fe, 
      Argentina.
FAU - Racca, Liliana
AU  - Racca L
AD  - Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
FAU - Palazzi, Jorge
AU  - Palazzi J
AD  - Center for Assistance and Comprehensive Clinical Research, Rosario, Mendoza, 
      Argentina.
FAU - Ghersevich, Sergio
AU  - Ghersevich S
AD  - Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de 
      Rosario, Rosario, Argentina.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - Q51BO43MG4 (Thyroxine)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Biomarkers/*blood
MH  - CD4-CD8 Ratio
MH  - Dehydroepiandrosterone Sulfate/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HIV Infections/*blood/drug therapy/immunology/metabolism
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Immune Reconstitution Inflammatory Syndrome/*blood/immunology/metabolism
MH  - Interleukin-18/blood
MH  - Interleukin-6/blood
MH  - Luminescence
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Thyroxine/blood
MH  - Viral Load
PMC - PMC10118694
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2018/04/26 06:00
MHDA- 2018/05/26 06:00
PMCR- 2018/01/01
CRDT- 2018/04/26 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/26 06:00 [pubmed]
PHST- 2018/05/26 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - S2359-39972018000100064 [pii]
AID - 2359-3997000000010 [pii]
AID - 10.20945/2359-3997000000010 [doi]
PST - ppublish
SO  - Arch Endocrinol Metab. 2018 Feb;62(1):64-71. doi: 10.20945/2359-3997000000010.