PMID- 29694884
OWN - NLM
STAT- MEDLINE
DCOM- 20191001
LR  - 20191001
IS  - 2211-1247 (Electronic)
VI  - 23
IP  - 4
DP  - 2018 Apr 24
TI  - Topographic Reorganization of Cerebrovascular Mural Cells under Seizure 
      Conditions.
PG  - 1045-1059
LID - S2211-1247(18)30486-8 [pii]
LID - 10.1016/j.celrep.2018.03.110 [doi]
AB  - Reorganization of the neurovascular unit has been suggested in the epileptic 
      brain, although the dynamics and functional significance remain unclear. Here, we 
      tracked the in vivo dynamics of perivascular mural cells as a function of 
      electroencephalogram (EEG) activity following status epilepticus. We segmented 
      the cortical vascular bed to provide a size- and type-specific analysis of mural 
      cell plasticity topologically. We find that mural cells are added and removed 
      from veins, arterioles, and capillaries after seizure induction. Loss of mural 
      cells is proportional to seizure severity and vascular pathology (e.g., rigidity, 
      perfusion, and permeability). Treatment with platelet-derived growth factor 
      subunits BB (PDGF-BB) reduced mural cell loss, vascular pathology, and 
      epileptiform EEG activity. We propose that perivascular mural cells play a 
      pivotal role in seizures and are potential targets for reducing pathophysiology.
CI  - Copyright (c) 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Arango-Lievano, Margarita
AU  - Arango-Lievano M
AD  - Departments of Neuroscience & Physiology, Laboratory of Stress Hormones & 
      Plasticity, Institut de Genomique Fonctionnelle, INSERM, CNRS, University of 
      Montpellier, 34093 Montpellier, France. Electronic address: 
      margarita.arango@igf.cnrs.fr.
FAU - Boussadia, Badreddine
AU  - Boussadia B
AD  - Department of Neuroscience, Laboratory of Cerebrovascular Mechanisms of Brain 
      Disorders, Institut de Genomique Fonctionnelle, INSERM, CNRS, University of 
      Montpellier, 34093 Montpellier, France.
FAU - De Terdonck, Lucile Du Trieu
AU  - De Terdonck LDT
AD  - Departments of Neuroscience & Physiology, Laboratory of Stress Hormones & 
      Plasticity, Institut de Genomique Fonctionnelle, INSERM, CNRS, University of 
      Montpellier, 34093 Montpellier, France.
FAU - Gault, Camille
AU  - Gault C
AD  - Departments of Neuroscience & Physiology, Laboratory of Stress Hormones & 
      Plasticity, Institut de Genomique Fonctionnelle, INSERM, CNRS, University of 
      Montpellier, 34093 Montpellier, France.
FAU - Fontanaud, Pierre
AU  - Fontanaud P
AD  - Department of Physiology, Laboratory of Networks and Rhythms in Endocrine Glands, 
      Institut de Genomique Fonctionnelle, INSERM, CNRS, University of Montpellier, 
      34093 Montpellier, France.
FAU - Lafont, Chrystel
AU  - Lafont C
AD  - Department of Physiology, Laboratory of Networks and Rhythms in Endocrine Glands, 
      Institut de Genomique Fonctionnelle, INSERM, CNRS, University of Montpellier, 
      34093 Montpellier, France.
FAU - Mollard, Patrice
AU  - Mollard P
AD  - Department of Physiology, Laboratory of Networks and Rhythms in Endocrine Glands, 
      Institut de Genomique Fonctionnelle, INSERM, CNRS, University of Montpellier, 
      34093 Montpellier, France.
FAU - Marchi, Nicola
AU  - Marchi N
AD  - Department of Neuroscience, Laboratory of Cerebrovascular Mechanisms of Brain 
      Disorders, Institut de Genomique Fonctionnelle, INSERM, CNRS, University of 
      Montpellier, 34093 Montpellier, France. Electronic address: 
      nicola.marchi@igf.cnrs.fr.
FAU - Jeanneteau, Freddy
AU  - Jeanneteau F
AD  - Departments of Neuroscience & Physiology, Laboratory of Stress Hormones & 
      Plasticity, Institut de Genomique Fonctionnelle, INSERM, CNRS, University of 
      Montpellier, 34093 Montpellier, France. Electronic address: 
      freddy.jeanneteau@igf.cnrs.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 1B56C968OA (Becaplermin)
SB  - IM
CIN - Epilepsy Curr. 2018 Nov-Dec;18(6):387-388. PMID: 30568556
MH  - Animals
MH  - Becaplermin/genetics/*metabolism
MH  - *Capillary Permeability
MH  - *Cerebral Arteries/metabolism/pathology/physiopathology
MH  - *Cerebral Veins/metabolism/pathology/physiopathology
MH  - Electroencephalography
MH  - Mice
MH  - Mice, Transgenic
MH  - *Status Epilepticus/genetics/metabolism/pathology/physiopathology
OTO - NOTNLM
OT  - PDGF-BB
OT  - PDGFR-B
OT  - blood flow
OT  - epilepsy
OT  - in vivo microscopy
OT  - neurovascular
OT  - pericyte
EDAT- 2018/04/26 06:00
MHDA- 2019/10/02 06:00
CRDT- 2018/04/26 06:00
PHST- 2017/06/13 00:00 [received]
PHST- 2018/01/04 00:00 [revised]
PHST- 2018/03/22 00:00 [accepted]
PHST- 2018/04/26 06:00 [entrez]
PHST- 2018/04/26 06:00 [pubmed]
PHST- 2019/10/02 06:00 [medline]
AID - S2211-1247(18)30486-8 [pii]
AID - 10.1016/j.celrep.2018.03.110 [doi]
PST - ppublish
SO  - Cell Rep. 2018 Apr 24;23(4):1045-1059. doi: 10.1016/j.celrep.2018.03.110.