PMID- 29695159
OWN - NLM
STAT- MEDLINE
DCOM- 20190424
LR  - 20190424
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 90
IP  - 11
DP  - 2018 Jun 5
TI  - Polymeric Sorbent with Controlled Surface Polarity: An Alternate for Solid-Phase 
      Extraction of Nerve Agents and Their Markers from Organic Matrix.
PG  - 7025-7032
LID - 10.1021/acs.analchem.8b01428 [doi]
AB  - Extraction and identification of lethal nerve agents and their markers in complex 
      organic background have a prime importance from the forensic and verification 
      viewpoint of the Chemical Weapons Convention (CWC). Liquid-liquid extraction with 
      acetonitrile and commercially available solid phase silica cartridges are 
      extensively used for this purpose. Silica cartridges exhibit limited 
      applicability for relatively polar analytes, and acetonitrile extraction shows 
      limited efficacy toward relatively nonpolar analytes. The present study describes 
      the synthesis of polymeric sorbents with tunable surface polarity, their 
      application as a solid-phase extraction (SPE) material against nerve agents and 
      their polar as well as nonpolar markers from nonpolar organic matrices. In 
      comparison with the acetonitrile extraction and commercial silica cartridges, the 
      new sorbent showed better extraction efficiency toward analytes of varying 
      polarity. The extraction parameters were optimized for the proposed method, which 
      included ethyl acetate as an extraction solvent and n-hexane as a washing 
      solvent. Under optimized conditions, method linearity ranged from 0.10 to 10 mug 
      mL(-1) ( r(2) = 0.9327-0.9988) for organophosphorus esters and 0.05-20 mug mL(-1) 
      ( r(2) = 0.9976-0.9991) for nerve agents. Limits of detection (S:N = 3:1) in the 
      SIM mode were found in the range of 0.03-0.075 mug mL(-1) for organophosphorus 
      esters and 0.015-0.025 mug mL(-1) for nerve agents. Limits of quantification (S:N 
      = 10:1) were found in the range of 0.100-0.25 mug mL(-1) for organophosphorus 
      esters and 0.05-0.100 mug mL(-1) for nerve agents in the SIM mode. The recoveries 
      of the nerve agents and their markers ranged from 90.0 to 98.0% and 75.0 to 95.0% 
      respectively. The repeatability and reproducibility (with relative standard 
      deviations (RSDs) %) for organophosphorus esters were found in the range of 
      1.35-8.61% and 2.30-9.25% respectively. For nerve agents, the repeatability range 
      from 1.00 to 7.75% and reproducibility were found in the range of 2.17-6.90%.
FAU - Roy, Kanchan Sinha
AU  - Roy KS
AUID- ORCID: 0000-0001-7726-6788
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior , 474002 Madhya Pradesh , India.
FAU - Purohit, Ajay Kumar
AU  - Purohit AK
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior , 474002 Madhya Pradesh , India.
FAU - Chandra, Buddhadeb
AU  - Chandra B
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior , 474002 Madhya Pradesh , India.
FAU - Goud, D Raghavender
AU  - Goud DR
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior , 474002 Madhya Pradesh , India.
FAU - Pardasani, Deepak
AU  - Pardasani D
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior , 474002 Madhya Pradesh , India.
FAU - Dubey, Devendra Kumar
AU  - Dubey DK
AUID- ORCID: 0000-0003-3820-2233
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior , 474002 Madhya Pradesh , India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180515
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Nerve Agents)
RN  - 0 (Polymers)
SB  - IM
MH  - Adsorption
MH  - Chemical Warfare Agents/*analysis
MH  - Molecular Structure
MH  - Nerve Agents/chemistry/*isolation & purification
MH  - Polymers/*chemistry
MH  - *Solid Phase Extraction
MH  - Surface Properties
EDAT- 2018/04/27 06:00
MHDA- 2019/04/25 06:00
CRDT- 2018/04/27 06:00
PHST- 2018/04/27 06:00 [pubmed]
PHST- 2019/04/25 06:00 [medline]
PHST- 2018/04/27 06:00 [entrez]
AID - 10.1021/acs.analchem.8b01428 [doi]
PST - ppublish
SO  - Anal Chem. 2018 Jun 5;90(11):7025-7032. doi: 10.1021/acs.analchem.8b01428. Epub 
      2018 May 15.