PMID- 29695401
OWN - NLM
STAT- MEDLINE
DCOM- 20181026
LR  - 20181114
IS  - 1790-6245 (Electronic)
IS  - 1109-6535 (Print)
IS  - 1109-6535 (Linking)
VI  - 15
IP  - 3
DP  - 2018 May-Jun
TI  - Cytogenetics of Spindle Cell/Pleomorphic Lipomas: Karyotyping and FISH Analysis 
      of 31 Tumors.
PG  - 193-200
AB  - BACKGROUND: Spindle cell/pleomorphic lipomas are benign tumors. Here, we present 
      our cytogenetic data on 31 such tumors. MATERIALS AND METHODS: G-banding 
      chromosome analysis and (in selected cases) fluorescence in situ hybridization 
      (FISH) using probes for FOXO1, RB1, and HMGA2 were performed. RESULTS: 
      Rearrangements of chromosome 13 were found in 58% of tumors. Chromosomes 6, 1, 
      12, and 11 were also involved in 42%, 26%, 26%, and 23% of tumors, respectively. 
      FISH analysis showed heterozygous deletion of RB1 in seven samples with 
      chromosome 13 aberrations. In four of them, FOXO1 was also deleted. In two tumors 
      with 12q15 rearrangements, FISH confirmed that HMGA2 was targeted. CONCLUSION: 
      Structural rearrangements of 13q or losses of an entire chromosome 13 are the 
      most common cytogenetic aberrations in spindle cell/pleomorphic lipomas. However, 
      cytogenetic variation exists similarly to what is found in other lipomas, 
      suggesting that various pathways may be responsible for tumorigenesis.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Panagopoulos, Ioannis
AU  - Panagopoulos I
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway 
      ioannis.panagopoulos@rr-research.no.
FAU - Gorunova, Ludmila
AU  - Gorunova L
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
FAU - Lund-Iversen, Marius
AU  - Lund-Iversen M
AD  - Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 
      Oslo, Norway.
FAU - Andersen, Kristin
AU  - Andersen K
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
FAU - Andersen, Hege Kilen
AU  - Andersen HK
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
FAU - Lobmaier, Ingvild
AU  - Lobmaier I
AD  - Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 
      Oslo, Norway.
FAU - Bjerkehagen, Bodil
AU  - Bjerkehagen B
AD  - Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 
      Oslo, Norway.
FAU - Heim, Sverre
AU  - Heim S
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Cancer Genomics Proteomics
JT  - Cancer genomics & proteomics
JID - 101188791
RN  - 0 (FOXO1 protein, human)
RN  - 0 (Forkhead Box Protein O1)
RN  - 0 (HMGA2 Protein)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RB1 protein, human)
RN  - 0 (Retinoblastoma Binding Proteins)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Forkhead Box Protein O1/genetics
MH  - HMGA2 Protein/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping/*methods
MH  - Lipoma/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics
MH  - Nevus, Spindle Cell/*genetics/pathology
MH  - Retinoblastoma Binding Proteins/genetics
MH  - Ubiquitin-Protein Ligases/genetics
PMC - PMC5971011
OTO - NOTNLM
OT  - FOXO1 gene
OT  - HMGA2 gene
OT  - RB1 gene
OT  - Spindle cell lipomas
OT  - chromosome 12
OT  - chromosome 13
OT  - cytogenetics
OT  - pleomorphic lipomas
EDAT- 2018/04/27 06:00
MHDA- 2018/10/27 06:00
PMCR- 2018/05/03
CRDT- 2018/04/27 06:00
PHST- 2017/12/29 00:00 [received]
PHST- 2018/02/17 00:00 [revised]
PHST- 2018/02/21 00:00 [accepted]
PHST- 2018/04/27 06:00 [entrez]
PHST- 2018/04/27 06:00 [pubmed]
PHST- 2018/10/27 06:00 [medline]
PHST- 2018/05/03 00:00 [pmc-release]
AID - 15/3/193 [pii]
AID - 10.21873/cgp.20077 [doi]
PST - ppublish
SO  - Cancer Genomics Proteomics. 2018 May-Jun;15(3):193-200. doi: 10.21873/cgp.20077.