PMID- 29695709
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20221207
IS  - 2044-4052 (Electronic)
IS  - 2044-4052 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Apr 25
TI  - Longitudinal association between egg consumption and the risk of cardiovascular 
      disease: interaction with type 2 diabetes mellitus.
PG  - 20
LID - 10.1038/s41387-018-0033-1 [doi]
LID - 20
AB  - BACKGROUND/OBJECTIVES: It remains unclear if high egg consumption has beneficial 
      or adverse effects on cardiometabolic health. The present study prospectively 
      evaluated the longitudinal association between egg-consumption levels and 
      incident cardiovascular disease (CVD) among Korean adults. SUBJECTS/METHODS: We 
      conducted a prospective cohort study of 9248 Korean adults aged 40-69 years 
      without CVD or cancer at the baseline from the Korean Genome and Epidemiology 
      Study, Ansung-Ansan cohort, South Korea. The egg intake of the participants was 
      estimated using a validated semiquantitative food frequency questionnaire at the 
      baseline and the second follow-up examination and categorized into quartiles. CVD 
      cases were identified using biennial questionnaires and confirmed through 
      repeated in-depth personal interviews. Hazard ratios (HR) and 95% confidence 
      interval (CI) were analyzed using Cox proportional hazard regression. RESULTS: 
      During the average follow-up of 7.3 years, 570 cases of CVD were newly diagnosed. 
      After adjusting for multiple confounding variables, egg-intake levels were not 
      associated with CVD incidence (HR: 1.14, 95% CI: 0.87-1.49, P for trend: 0.7). 
      However, the association was modified by type 2 diabetes mellitus (T2DM) status. 
      Egg consumption was significantly associated with an increased risk for incident 
      CVD among participants with T2DM; individuals with the highest egg intake 
      (4.2 +/- 0.04 eggs/week) had a 2.8 times higher incidence of CVD (HR: 2.81, 95% CI: 
      1.25-6.30, P for trend: 0.02) than those with the lowest egg intake 
      (0.1 +/- 0.02 eggs/week). However, no association was observed among individuals 
      without T2DM (HR: 1.03, 95% CI: 0.77-1.38, P for trend: 0.8). CONCLUSIONS: Higher 
      egg consumption may increase the risk for CVD in Korean patients with T2DM. Our 
      findings provide a basis for the development of an optimal dietary cholesterol 
      intake guideline for the Korean population.
FAU - Jang, Jiyoung
AU  - Jang J
AD  - Department of Food and Nutrition, Yeungnam University, Gyeongsan, Republic of 
      Korea.
FAU - Shin, Min-Jeong
AU  - Shin MJ
AD  - Department of Public Health Sciences, BK21PLUS Program in Embodiment: 
      Health-Society Interaction, Graduate School, Korea University, Seoul, Republic of 
      Korea.
FAU - Kim, Oh Yoen
AU  - Kim OY
AD  - Department of Food Science and Nutrition, Dong-A University, Busan, Republic of 
      Korea.
FAU - Park, Kyong
AU  - Park K
AUID- ORCID: 0000-0002-4681-1584
AD  - Department of Food and Nutrition, Yeungnam University, Gyeongsan, Republic of 
      Korea. kypark@ynu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180425
PL  - England
TA  - Nutr Diabetes
JT  - Nutrition & diabetes
JID - 101566341
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Cardiovascular Diseases/*etiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - *Diet
MH  - Diet Surveys
MH  - Eggs/*adverse effects
MH  - *Feeding Behavior
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Republic of Korea
MH  - Surveys and Questionnaires
PMC - PMC5916923
COIS- The authors declare no conflicts of interest.
EDAT- 2018/04/27 06:00
MHDA- 2019/03/16 06:00
PMCR- 2018/04/25
CRDT- 2018/04/27 06:00
PHST- 2017/11/21 00:00 [received]
PHST- 2018/03/16 00:00 [accepted]
PHST- 2018/03/04 00:00 [revised]
PHST- 2018/04/27 06:00 [entrez]
PHST- 2018/04/27 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2018/04/25 00:00 [pmc-release]
AID - 10.1038/s41387-018-0033-1 [pii]
AID - 33 [pii]
AID - 10.1038/s41387-018-0033-1 [doi]
PST - epublish
SO  - Nutr Diabetes. 2018 Apr 25;8(1):20. doi: 10.1038/s41387-018-0033-1.