PMID- 29696157 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220317 IS - 2451-8654 (Electronic) IS - 2451-8654 (Linking) VI - 10 DP - 2018 Jun TI - Design and outcomes of the Patient Centered Outcomes Research Institute coronary heart disease cohort study. PG - 42-49 LID - 10.1016/j.conctc.2018.03.001 [doi] AB - BACKGROUND: The Patient Centered Outcomes Research Institute (PCORI) established Clinical Data Research Networks (CDRNs) to support pragmatic research. The objective was to electronically identify, recruit, and survey coronary heart disease (CHD) patients and describe their characteristics, health status, and willingness to participate in future research. METHODS: We developed a computable phenotype and assembled CHD patients 30 years or older and had visits or hospitalizations between 2009 and 2015. A sample of patients was surveyed between August 2014 and September 2015. Survey administration included the following methods: face-to-face, telephone, paper or web portal. Survey items covered broad domains including: health literacy and numeracy, and socio-demographics, physical and mental health, health behaviors, access to medical care, and willingness to participate in future research. RESULTS: Of 5517 approached patients, 2605 completed the survey. Participants were mostly white ( approximately 88%), male (68%) and had a median age of 69 years (interquartile range [IQR] 61-76 years). Most respondents' health literacy and numeracy were adequate (83.2% and 84.3%, respectively). Only 4% of respondents reported that their overall health or physical health was excellent. The majority ( approximately 58%) reported that their health was good or very good, while 40% reported that their general and physical health were fair or poor. The majority reported that their quality of life was good to excellent (81%). Limitations in physical health and function were common, including often/always having fatigue (25%), pain (38.7%), or sleep difficulty (19.7%). A patient sample (n = 1936) was provided with a trial summary which would randomize their aspirin dose; and 63% reported that they would consider participating. CONCLUSION: Many patients with CHD had limitations in physical health. However, the majority reported a good or excellent quality of life. FAU - Roumie, Christianne L AU - Roumie CL AD - Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research Education Clinical Center (GRECC), HSR&D Center, Nashville, TN, United States. AD - Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Patel, Niral J AU - Patel NJ AD - Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Munoz, Daniel AU - Munoz D AD - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Bachmann, Justin AU - Bachmann J AD - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Stahl, Ashton AU - Stahl A AD - Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Case, Ryan AU - Case R AD - Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Leak, Cardella AU - Leak C AD - Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Rothman, Russell AU - Rothman R AD - Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, TN, United States. FAU - Kripalani, Sunil AU - Kripalani S AD - Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United States. AD - Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, TN, United States. LA - eng GR - K12 HS022990/HS/AHRQ HHS/United States PT - Journal Article DEP - 20180309 PL - Netherlands TA - Contemp Clin Trials Commun JT - Contemporary clinical trials communications JID - 101671157 PMC - PMC5898539 EDAT- 2018/04/27 06:00 MHDA- 2018/04/27 06:01 PMCR- 2018/03/09 CRDT- 2018/04/27 06:00 PHST- 2017/09/22 00:00 [received] PHST- 2018/02/16 00:00 [revised] PHST- 2018/03/08 00:00 [accepted] PHST- 2018/04/27 06:00 [entrez] PHST- 2018/04/27 06:00 [pubmed] PHST- 2018/04/27 06:01 [medline] PHST- 2018/03/09 00:00 [pmc-release] AID - S2451-8654(17)30165-5 [pii] AID - 10.1016/j.conctc.2018.03.001 [doi] PST - epublish SO - Contemp Clin Trials Commun. 2018 Mar 9;10:42-49. doi: 10.1016/j.conctc.2018.03.001. eCollection 2018 Jun.